The Potential of Single‐Chain Variable Fragment Antibody: Role in Future Therapeutic and Diagnostic Biologics
G Gezehagn Kussia… - Journal of Immunology …, 2024 - Wiley Online Library
The advancement of genetic engineering has revolutionized the field of immunology by
allowing the utilization of intrinsic antibody structures. One of the biologics that are being …
allowing the utilization of intrinsic antibody structures. One of the biologics that are being …
Chimeric antigen receptor-natural killer cells: a promising sword against insidious tumor cells
T Hojjatipour, Z Sharifzadeh, A Maali, M Azad - Human Cell, 2023 - Springer
Natural killer (NK) cells are a critical component of innate immunity, particularly in initial
cancer recognition and inhibition of additional tumor growth or metastasis propagation. NK …
cancer recognition and inhibition of additional tumor growth or metastasis propagation. NK …
[HTML][HTML] Changes in the behavior of Staphylococcus aureus strains in the presence of oxacillin under the effect of gamma radiation
Staphylococcus aureus (S. aureus) as a major pathogen is implicated in a wide range of
foodborne and hospital-acquired infections, its methicillin resistant variants contribute to the …
foodborne and hospital-acquired infections, its methicillin resistant variants contribute to the …
Anti-Acinetobacter baumannii single-chain variable fragments provide therapeutic efficacy in an immunocompromised mouse pneumonia model
E Basardeh, S Piri-Gavgani, HR Moradi, M Azizi… - BMC microbiology, 2024 - Springer
Background The emergence of carbapenem-resistant and extensively drug-resistant (XDR)
Acinetobacter baumannii as well as inadequate effective antibiotics calls for an urgent effort …
Acinetobacter baumannii as well as inadequate effective antibiotics calls for an urgent effort …
Identification of a novel fully human anti-toxic shock syndrome toxin (TSST)-1 single-chain variable fragment antibody averting TSST-1-induced mitogenesis and …
Background Staphylococcal superantigens are virulence factors that help the pathogen
escape the immune system and develop an infection. Toxic shock syndrome toxin (TSST)-1 …
escape the immune system and develop an infection. Toxic shock syndrome toxin (TSST)-1 …
[HTML][HTML] Identification of two neutralizing human single-chain variable fragment antibodies targeting Staphylococcus aureus alpha-hemolysin
Objective (s): The inability of the host immune system to defeat Staphylococcus aureus is
due to various secreted virulent factors such as leukocidins, superantigens, and hemolysins …
due to various secreted virulent factors such as leukocidins, superantigens, and hemolysins …
[HTML][HTML] Anti-Acinetobacter baumannii single-chain variable fragments show direct bactericidal activity
E Basardeh, S Piri-Gavgani… - Iranian Journal of …, 2022 - ncbi.nlm.nih.gov
Objective (s): The high resistance rate of Acinetobacter baumannii and the limited number of
available antibiotics have prompted a worldwide effort to develop effective antimicrobial …
available antibiotics have prompted a worldwide effort to develop effective antimicrobial …
Novel approaches for bacterial toxin neutralization; current advances and future perspectives
M Doroudian, M Afshar Ardalan… - QJM: An International …, 2024 - academic.oup.com
This review outlines diverse strategies for neutralizing bacterial toxins which are a significant
threat to human health. Effective toxin neutralization is crucial in preventing and treating …
threat to human health. Effective toxin neutralization is crucial in preventing and treating …
Two novel single-chain variable fragments exert bactericidal activity against Acinetobacter baumannii through destabilization of the outer membrane
F Rahimi-Jamnani - 2024 - researchsquare.com
Acinetobacter baumannii is notorious for its high levels of resistance and the development of
clinically-effective antimicrobial agents seems to be an urgent medical challenge …
clinically-effective antimicrobial agents seems to be an urgent medical challenge …
The Therapeutic Efficacy of MS473, a Fully Human Single-Chain Variable Fragment Specific to Staphylococcus aureus Toxic Shock Syndrome Toxin-1, in a Mouse …
FR Jamnani, HR Moradi, M Soezi, M Azizi, F Nazari… - 2024 - researchsquare.com
Toxic shock syndrome toxin-1 (TSST-1), produced by Staphylococcus aureus, is one of the
most potent superantigens involved in causing life-threatening toxic shock syndrome (TSS) …
most potent superantigens involved in causing life-threatening toxic shock syndrome (TSS) …