Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by demyelination, with a relative sparing of axons. In MS patients, many …

The somatodendritic subthreshold A-type K+ current (ISA) in nerve cells is a critical
component of the ensemble of voltage-gated ionic currents that determine somatodendritic …

Potassium channels share a highly conserved stretch of eight amino acids, a K+ channel
signature sequence. The conserved sequence falls within the previously defined P-region of …

In the brain and heart, rapidly inactivating (A-type) voltage-gated potassium (Kv) currents
operate at subthreshold membrane potentials to control the excitability of neurons and …

A complementary DNA encoding an inward rectifier K+ channel (IRK1) was isolated from a
mouse macrophage cell line by expression cloning. This channel conducts inward K+ …

A complementary DNA encoding an ATP-regulated potassium channel has been isolated by
expression cloning from rat kidney. The predicted 45K protein, which features two potential …

We have examined gating and pharmacological characteristics of somatic K+ channels in
fast-spiking interneurons and regularly spiking principal neurons of hippocampal slices. In …

Serôdio, Paulo and Bernardo Rudy. Differential expression of Kv4 K+ channel subunits
mediating subthreshold transient K+ (A-type) currents in rat brain. J. Neurophysiol. 79: 1081 …

The expression of 15 different K+ channels in canine heart was examined, and a new K+
channel gene (Kv4. 3), which encodes a rapidly inactivating K+ current, is described. The …

In the mammalian nervous system, K+ channels regulate diverse aspects of neuronal
function and are encoded by a large set of K+ channel genes. The roles of different K+ …