About two decades after Kobayashi's discovery in 1983 of a very mild way of generating
highly reactive aryne intermediates, the synthetic community embraced o-(trimethylsilyl) aryl …

Since its first observation in 1907, ortho-quinone methide (o-QM) has occupied a strategic
place within the framework of reactive intermediates in organic synthesis. In recent years, o …

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Widespread resistance to first-line TB drugs is a major problem that will likely only be
resolved through the development of new drugs with novel mechanisms of action. We have …

Abstract Development of new methods of heterocyclic synthesis is still a topical issue. In this
connection, the trend related to the use of highly reactive o-quinone methides for the …

A novel and efficient method for the generation of o-quinone methide intermediates was
developed from the readily available 2-tosylalkylphenols under the mild basic conditions …

The review summarizes and systematizes the [4+ 2]-cycloaddition reactions of o-quinone
methides with electron-rich and electron-deficient olefins. The electron-rich substrates …

A simple and efficient method for the synthesis of 4 H-chromenes and 1 H-benzo [f]
chromenes containing a trifluoroacetyl or aroyl group in the pyran ring from o-quinone …

Over the years, quinone methides have broadly been applied in synthesis and biological
systems for synthesizing heterocyclic compounds and biologically active molecules. In this …

The synthesis of α-aryl ketones is accomplished by the direct nucleophilic acylation of o-
quinone methide electrophiles. In this process, two reactive intermediates, carbonyl anions …