As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or
mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress …

Chimeric antigen receptors (CAR) are engineered fusion proteins constructed from antigen
recognition, signaling, and costimulatory domains that can be expressed in cytotoxic T cells …

A compact marker/suicide gene that utilizes established clinical-grade reagents and
pharmaceuticals would be of considerable practical utility to T-cell cancer gene therapy …

Clinical-grade T cells are genetically modified ex vivo to express a chimeric antigen receptor
(CAR) to redirect specificity to a tumor associated antigen (TAA) thereby conferring antitumor …

Immunotherapy with T cells expressing the chimeric antigen receptor (CAR) specific for the
CD19 antigen (CD19. CAR-Ts) is a very effective treatment in B cell lymphoid malignancies …

To develop a therapy for drug-resistant B-lineage acute lymphoblastic leukemia (ALL), we
transduced T lymphocytes with anti-CD19 chimeric receptors, consisting of an anti-CD19 …

The efficacy of adoptive T-cell therapy as treatment for malignancies may be enhanced by
genetic modification of infused cells. However, oncogenic events due to vector/transgene …

Infusions of antigen-specific T cells have yielded therapeutic responses in patients with
pathogens and tumors. To broaden the clinical application of adoptive immunotherapy …

Rituximab is an anti-CD20 chimeric mAb effective for the treatment of B-NHL. It can lyse
lymphoma cells in vitro through both C-and Ab-dependent cellular cytotoxicity. The …

We and others previously reported potent antileukemia efficacy of CD123-redirected
chimeric antigen receptor (CAR) T cells in preclinical human acute myeloid leukemia (AML) …