The landscape of mRNA nanomedicine
Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and
treatment of a wide range of diseases. The recent success of the two highly efficacious …
treatment of a wide range of diseases. The recent success of the two highly efficacious …
The clinical progress of mRNA vaccines and immunotherapies
The emergency use authorizations (EUAs) of two mRNA-based severe acute respiratory
syndrome coronavirus (SARS-CoV)-2 vaccines approximately 11 months after publication of …
syndrome coronavirus (SARS-CoV)-2 vaccines approximately 11 months after publication of …
mRNA-based therapeutics: powerful and versatile tools to combat diseases
S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
The cGAS–STING pathway and cancer
N Samson, A Ablasser - Nature cancer, 2022 - nature.com
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
mRNA-based cancer therapeutics
Due to the fact that mRNA technology allows the production of diverse vaccines and
treatments in a shorter time frame and with reduced expense compared to conventional …
treatments in a shorter time frame and with reduced expense compared to conventional …
Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment
Decades have passed since the first nanoparticles-base medicine was approved for human
cancer treatment, and the research and development of nanoparticles for drug delivery are …
cancer treatment, and the research and development of nanoparticles for drug delivery are …
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines
The use of lipid-formulated RNA vaccines for cancer or COVID-19 is associated with dose-
limiting systemic inflammatory responses in humans that were not predicted from preclinical …
limiting systemic inflammatory responses in humans that were not predicted from preclinical …
Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis
Safe and efficacious systemic delivery of messenger RNA (mRNA) to specific organs and
cells in vivo remains the major challenge in the development of mRNA-based therapeutics …
cells in vivo remains the major challenge in the development of mRNA-based therapeutics …
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
N Chaudhary, D Weissman… - Nature reviews Drug …, 2021 - nature.com
Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a
scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the …
scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the …
An ionizable lipid toolbox for RNA delivery
Recent years have witnessed incredible growth in RNA therapeutics, which has benefited
significantly from decades of research on lipid nanoparticles, specifically its key component …
significantly from decades of research on lipid nanoparticles, specifically its key component …