The past 20 years have seen the definition of human monogenic disorders and their
autoimmune phenocopies underlying either defective or enhanced type I interferon (IFN) …

RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …

Metabolic rewiring is often considered an adaptive pressure limiting metastasis formation;
however, some nutrients available at distant organs may inherently promote metastatic …

Detailed knowledge of the molecular biology of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection is crucial for understanding of viral replication, host …

Interferon regulatory factor 7 (IRF7), a member of the interferon regulatory factors (IRFs)
family, is located downstream of the pattern recognition receptors (PRRs)-mediated …

The interferon regulatory factor (IRF) family of transcription factors play a vital role in the
human innate antiviral immune responses with production of interferons (IFNs) as a hallmark …

Human SARS‐CoV‐2 infection is characterized by a high mortality rate due to some patients
developing a large innate immune response associated with a cytokine storm and acute …

Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global health threat …

Type I Interferon (IFN-I) responses were first recognized for their role in antiviral immunity,
but it is now widely appreciated that IFN-Is have many immunomodulatory functions …

Abstract Fas/Fas ligand (FasL)-mediated cell apoptosis involves a variety of physiological
and pathological processes including chronic hepatic diseases, and hepatocytes apoptosis …