As an indispensable micronutrient, copper (Cu) plays an important role in promoting
metabolism and maintaining various basic biological functions. Copper homeostasis in the …

Copper is an essential transition metal frequently increased in cancer known to strongly
influence essential cellular processes. Targeted therapy protocols utilizing both novel and …

To develop potential next-generation metal anticancer agents, we designed and
synthesised five Cu (II) 2-pyridine-thiosemicarbazone complexes by modifying the hydrogen …

Considering the fundamental role of protein kinases in the mechanism of protein
phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has …

Colorectal carcinoma is a complex malignancy and current therapies are hampered by
systemic toxicity and tumor resistance to treatment. In the field of cancer therapy, copper …

Bis (pyrazol-1-yl)-and bis (3, 5-dimethylpyrazol-1-yl)-acetates were conjugated with the 2-
hydroxyethylester and 2-aminoethylamide derivatives of the antineoplastic drug lonidamine …

Mitochondria have various cellular functions, including ATP synthesis, calcium homeostasis,
cell senescence, and death. Mitochondrial dysfunction has been identified in a variety of …

Worldwide, colon cancer (CC) represents the fourth most common type of cancer and the
fifth major cause of cancer-associated deaths. Surgical resection is considered the standard …

Aim: Preclinical evaluation of a cytotoxic copper (II) complex formulated in long circulating
nanoliposomes for melanoma treatment. Materials & methods: Liposomal nanoformulations …

Melanoma is an aggressive form of skin cancer, being one of the deadliest cancers in the
world. The current treatment options involve surgery, radiotherapy, targeted therapy …