Background Metastasis is the main cause of mortality in cancer patients. Two major routes of
cancer cell spread are currently being recognized: dissemination via blood vessels …

New growth in the vascular network is important since the proliferation, as well as metastatic
spread, of cancer cells depends on an adequate supply of oxygen and nutrients and the …

Multi-modal imaging guided photothermal therapy with single-walled carbon nanotubes
affords effective destruction of primary tumors together with cancer cells in sentinel lymph …

The lymphatic vasculature forms a vessel network that drains interstitial fluid from tissues
and returns it to the blood. Lymphatic vessels are also an essential part of the body's …

Lymphatic metastasis contributes to mortality from solid tumors. Whether metastasizing
cancer cells reach lymph nodes via intratumor lymphatic vessels is unknown. Here, we …

Tumour blood vessels express markers that are not present in resting blood vessels of
normal tissues, but that can be shared by angiogenic vessels in non-malignant conditions …

Metastasis is a frequent and lethal complication of cancer. Vascular endothelial growth
factor‐C (VEGF‐C) is a recently described lymphangiogenic factor. Increased expression of …

Studies of the last decades have revealed the importance of angiogenesis for normal growth
and for the pathogenesis of numerous diseases. Much less studied is lymphangiogenesis …

Lymphatic vessels are important for the spread of solid tumours, but the mechanisms that
underlie lymphatic spread and the role of lymphangiogenesis (the growth of lymphatics) in …

Extracellular proteolysis is an absolute requirement for new blood vessel formation
(angiogenesis). This review examines the role of the matrix metalloproteinase (MMP) and …