Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …

Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …

3′-untranslated regions (3′-UTRs) are the noncoding parts of mRNAs. Compared to
yeast, in humans, median 3′-UTR length has expanded approximately tenfold alongside …

Stimulated cells and cancer cells have widespread shortening of mRNA 3'-untranslated
regions (3'UTRs) and switches to shorter mRNA isoforms due to usage of more proximal …

Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …

Subsets of mammalian adult stem cells reside in the quiescent state for prolonged periods of
time. This state, which is reversible, has long been viewed as dormant and with minimal …

The 3′ end of most protein-coding genes and long non-coding RNAs is cleaved and
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …

Generated by 3′ end cleavage and polyadenylation at alternative polyadenylation (poly
(A)) sites, alternative terminal exons account for much of the variation between human …

The human transcriptome comprises> 80000 protein-coding transcripts and the estimated
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …

There is now compelling evidence that the complexity of higher organisms correlates with
the relative amount of non-coding RNA rather than the number of protein-coding genes …