Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition
Amyotrophic lateral sclerosis (ALS) is characterized by nucleocytoplasmic mislocalization of
the RNA-binding protein (RBP) TDP-43. However, emerging evidence suggests more …
the RNA-binding protein (RBP) TDP-43. However, emerging evidence suggests more …
mRNA transport in fungal top models
D Niessing, RP Jansen, T Pohlmann… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
Eukaryotic cells rely on the precise determination of when and where proteins are
synthesized. Spatiotemporal expression is supported by localization of mRNAs to specific …
synthesized. Spatiotemporal expression is supported by localization of mRNAs to specific …
The many functions of mRNA localization during normal development and disease: from pillar to post
NAL Cody, C Iampietro… - Wiley Interdisciplinary …, 2013 - Wiley Online Library
The regulated intracellular trafficking and localized translation of mRNA molecules
represents an important and prevalent mechanism of gene regulation. This process plays a …
represents an important and prevalent mechanism of gene regulation. This process plays a …
High-throughput identification of RNA localization elements in neuronal cells
Hundreds of RNAs are enriched in the projections of neuronal cells. For the vast majority of
them, though, the sequence elements that regulate their localization are unknown. To …
them, though, the sequence elements that regulate their localization are unknown. To …
Peroxisome function relies on organelle-associated mRNA translation
N Dahan, YS Bykov, EA Boydston, A Fadel, Z Gazi… - Science …, 2022 - science.org
Crucial metabolic functions of peroxisomes rely on a variety of peroxisomal membrane
proteins (PMPs). While mRNA transcripts of PMPs were shown to be colocalized with …
proteins (PMPs). While mRNA transcripts of PMPs were shown to be colocalized with …
Identification of a cis-acting element that localizes mRNA to synapses
Messenger RNA (mRNA) localization and regulated translation can spatially restrict gene
expression to each of the thousands of synaptic compartments formed by a single neuron …
expression to each of the thousands of synaptic compartments formed by a single neuron …
Multifunctional roles for the protein translocation machinery in RNA anchoring to the endoplasmic reticulum
Signal sequence-encoding mRNAs undergo translation-dependent localization to the
endoplasmic reticulum (ER) and at the ER are anchored via translation on Sec61-bound …
endoplasmic reticulum (ER) and at the ER are anchored via translation on Sec61-bound …
A secretion-enhancing cis regulatory targeting element (SECReTE) involved in mRNA localization and protein synthesis
O Cohen-Zontag, C Baez, LQJ Lim, T Olender… - PLoS …, 2019 - journals.plos.org
The localization of mRNAs encoding secreted/membrane proteins (mSMPs) to the
endoplasmic reticulum (ER) likely facilitates the co-translational translocation of secreted …
endoplasmic reticulum (ER) likely facilitates the co-translational translocation of secreted …
Multifunctional RNA binding protein OsTudor-SN in storage protein mRNA transport and localization
The multifunctional RNA-binding protein Tudor-SN plays multiple roles in transcriptional and
posttranscriptional processes due to its modular domain structure, consisting of four tandem …
posttranscriptional processes due to its modular domain structure, consisting of four tandem …
Localization elements and zip codes in the intracellular transport and localization of messenger RNAs in Saccharomyces cerevisiae
Intracellular trafficking and localization of mRNAs provide a mechanism of regulation of
expression of genes with excellent spatial control. mRNA localization followed by localized …
expression of genes with excellent spatial control. mRNA localization followed by localized …