Restless legs syndrome

M Manconi, D Garcia-Borreguero… - Nature reviews Disease …, 2021 - nature.com
Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by an urge
to move that appears during rest or is exacerbated by rest, that occurs in the evening or night …

Sleep disorders in people with type 2 diabetes and associated health outcomes: a review of the literature

SBJ Schipper, MM Van Veen, PJM Elders… - Diabetologia, 2021 - Springer
Sleep disorders are linked to development of type 2 diabetes and increase the risk of
developing diabetes complications. Treating sleep disorders might therefore play an …

The economic cost of inadequate sleep

D Hillman, S Mitchell, J Streatfeild, C Burns, D Bruck… - Sleep, 2018 - academic.oup.com
Abstract Study Objectives To estimate the economic cost (financial and nonfinancial) of
inadequate sleep in Australia for the 2016–2017 financial year and relate this to likely costs …

Comorbidities, treatment, and pathophysiology in restless legs syndrome

C Trenkwalder, R Allen, B Högl, S Clemens… - The Lancet …, 2018 - thelancet.com
Restless legs syndrome, also known as Willis-Ekbom disease, is a common neurological
condition whose manifestation is affected by complex environmental and genetic …

[HTML][HTML] Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an …

RP Allen, DL Picchietti, M Auerbach, YW Cho… - Sleep medicine, 2018 - Elsevier
Background Brain iron deficiency has been implicated in the pathophysiology of RLS, and
current RLS treatment guidelines recommend iron treatment when peripheral iron levels are …

Sleep disorders in the elderly: Diagnosis and management

K Suzuki, M Miyamoto, K Hirata - Journal of general and family …, 2017 - Wiley Online Library
Compared with younger people, elderly people show age‐related sleep changes, including
an advanced sleep phase and decreased slow‐wave sleep, which result in fragmented …

[HTML][HTML] Restless legs syndrome: contemporary diagnosis and treatment

TR Gossard, LM Trotti, A Videnovic, EK St Louis - Neurotherapeutics, 2021 - Elsevier
Restless legs syndrome (RLS) is characterized by an uncomfortable urge to move the legs
while at rest, relief upon movement or getting up to walk, and worsened symptom severity at …

Restless legs syndrome associated with major diseases: a systematic review and new concept

C Trenkwalder, R Allen, B Högl, W Paulus… - Neurology, 2016 - AAN Enterprises
Recent publications on both the genetics and environmental factors of restless legs
syndrome (RLS) defined as a clinical disorder suggest that overlapping genetic risk factors …

The social and economic cost of sleep disorders

J Streatfeild, J Smith, D Mansfield, L Pezzullo… - Sleep, 2021 - academic.oup.com
Abstract Study Objectives To estimate economic cost of common sleep disorders in Australia
for 2019–2020. Methods Costs were estimated for obstructive sleep apnea (OSA), insomnia …

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis

B Schormair, C Zhao, S Bell, E Tilch… - The Lancet …, 2017 - thelancet.com
Background Restless legs syndrome is a prevalent chronic neurological disorder with
potentially severe mental and physical health consequences. Clearer understanding of the …