Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications
Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
Mitochondria‐targeted nanoparticles in treatment of neurodegenerative diseases
Y Zhang, H Yang, D Wei, X Zhang, J Wang, X Wu… - …, 2021 - Wiley Online Library
Neurodegenerative diseases (NDs) are a class of heterogeneous diseases that includes
Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral …
Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral …
Polymeric Nanoparticles for Drug Delivery
MA Beach, U Nayanathara, Y Gao, C Zhang… - Chemical …, 2024 - ACS Publications
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …
necessitated the creation of more sophisticated drug delivery systems. Polymeric …
Mitochondrial dysfunction, oxidative stress, and therapeutic strategies in diabetes, obesity, and cardiovascular disease
KA Cojocaru, I Luchian, A Goriuc, LM Antoci… - Antioxidants, 2023 - mdpi.com
Mitochondria are subcellular organelles involved in essential cellular functions, including
cytosolic calcium regulation, cell apoptosis, and reactive oxygen species production. They …
cytosolic calcium regulation, cell apoptosis, and reactive oxygen species production. They …
Boosting cancer therapy with organelle-targeted nanomaterials
P Gao, W Pan, N Li, B Tang - ACS applied materials & interfaces, 2019 - ACS Publications
The ultimate goal of cancer therapy is to eliminate malignant tumors while causing no
damage to normal tissues. In the past decades, numerous nanoagents have been employed …
damage to normal tissues. In the past decades, numerous nanoagents have been employed …
Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting
X Fu, Y Shi, T Qi, S Qiu, Y Huang, X Zhao… - Signal transduction and …, 2020 - nature.com
Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to
reach their final targets. The optimal targets of most cancer therapeutic agents are usually …
reach their final targets. The optimal targets of most cancer therapeutic agents are usually …
Altered mitochondrial function in insulin-deficient and insulin-resistant states
GN Ruegsegger, AL Creo, TM Cortes… - The Journal of …, 2018 - Am Soc Clin Investig
Diabetes profoundly alters fuel metabolism; both insulin deficiency and insulin resistance
are characterized by inefficient mitochondrial coupling and excessive production of reactive …
are characterized by inefficient mitochondrial coupling and excessive production of reactive …
DNA-unresponsive platinum (II) complex induces ERS-mediated mitophagy in cancer cells
Y Guo, S Jin, H Yuan, T Yang, K Wang… - Journal of Medicinal …, 2021 - ACS Publications
Mitophagy is a selective autophagic process that degrades dysfunctional mitochondria.
Monofunctional platinum (II) complexes are candidates for anticancer drugs with the …
Monofunctional platinum (II) complexes are candidates for anticancer drugs with the …
Mitochondria-targeted tetrahedral DNA nanostructures for doxorubicin delivery and enhancement of apoptosis
J Yan, J Chen, N Zhang, Y Yang, W Zhu… - Journal of Materials …, 2020 - pubs.rsc.org
Mitochondria-targeted nanoparticles, such as liposomes, polymers and inorganic particles,
suffer from heterogeneity, low biocompatibility and low drug loading efficiency. Here, we …
suffer from heterogeneity, low biocompatibility and low drug loading efficiency. Here, we …
Gram-scale synthesis of highly biocompatible and intravenous injectable hafnium oxide nanocrystal with enhanced radiotherapy efficacy for cancer theranostic
Y Li, Y Qi, H Zhang, Z Xia, T Xie, W Li, D Zhong, H Zhu… - Biomaterials, 2020 - Elsevier
Based on the ionizing radiation applied to the malignant tumor tissue, radiation therapy (RT)
is the frequently-used non-surgical approach for cancer treatment. Hafnium Oxide (HfO 2) …
is the frequently-used non-surgical approach for cancer treatment. Hafnium Oxide (HfO 2) …