Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Neurodegenerative diseases (NDs) are a class of heterogeneous diseases that includes
Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral …

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

Mitochondria are subcellular organelles involved in essential cellular functions, including
cytosolic calcium regulation, cell apoptosis, and reactive oxygen species production. They …

The ultimate goal of cancer therapy is to eliminate malignant tumors while causing no
damage to normal tissues. In the past decades, numerous nanoagents have been employed …

Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to
reach their final targets. The optimal targets of most cancer therapeutic agents are usually …

Diabetes profoundly alters fuel metabolism; both insulin deficiency and insulin resistance
are characterized by inefficient mitochondrial coupling and excessive production of reactive …

Mitophagy is a selective autophagic process that degrades dysfunctional mitochondria.
Monofunctional platinum (II) complexes are candidates for anticancer drugs with the …

Mitochondria-targeted nanoparticles, such as liposomes, polymers and inorganic particles,
suffer from heterogeneity, low biocompatibility and low drug loading efficiency. Here, we …

Based on the ionizing radiation applied to the malignant tumor tissue, radiation therapy (RT)
is the frequently-used non-surgical approach for cancer treatment. Hafnium Oxide (HfO 2) …