Abstract Phospholipase A 2 (PLA 2) enzymes are involved in various inflammatory
pathological conditions including arthritis, cardiovascular and autoimmune diseases. The …

ABSTRACT Phospholipase A2 (PLA2) enzymes are implicated in several pathological
conditions such as arthritis, cardiovascular diseases, and diabetes. It is highly important to …

Introduction: The regulation of the catalytic activity of the various phospholipase A2 enzymes
is of high importance because these enzymes are involved in various pathological …

Abstract Phospholipases A2 (PLA2s) overexpression is closely associated with the
malignant potential of breast cancers. Here, we showed for the first the antitumoral effects of …

Elevated blood glucose and increased activities of secreted phospholipase A2 (sPLA2) are
strongly linked to coronary heart disease. In this report, our goal was to develop small …

The inflammatory process is a natural self-defense response of the organism to damage
agents and its action mechanism involves a series of complex reactions. However, in some …

Peptide drug discovery may play a key role in the identification of novel medicinal agents.
Here, we present the development of novel small peptides able to suppress the production …

Scutellaria baicalensis Georgi (S. baicalensis) is a traditional Chinese medicine that has
been used in the treatment of diabetes for centuries. Although it has curative effects on …

The quest for novel agents to regulate the generation of prostaglandin E2 (PGE2) is of high
importance because this eicosanoid is a key player in inflammatory diseases. We …

Prostaglandin E2 (PGE2) is a key mediator of inflammation, and consequently huge efforts
have been devoted to the development of novel agents able to regulate its formation. In this …