Structural biology of SARS-CoV-2: open the door for novel therapies

W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …

SARS-CoV-2 accessory proteins in viral pathogenesis: knowns and unknowns

N Redondo, S Zaldívar-López, JJ Garrido… - Frontiers in …, 2021 - frontiersin.org
There are still many unanswered questions concerning viral SARS-CoV-2 pathogenesis in
COVID-19. Accessory proteins in SARS-CoV-2 consist of eleven viral proteins whose roles …

Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host

ST Sonnleitner, M Prelog, S Sonnleitner… - Nature …, 2022 - nature.com
Different scenarios explaining the emergence of novel variants of concern (VOC) of the
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported …

The role of B cells in COVID-19 infection and vaccination

S Chen, F Guan, F Candotti, K Benlagha… - Frontiers in …, 2022 - frontiersin.org
B cells secrete antibodies and mediate the humoral immune response, making them
extremely important in protective immunity against SARS-CoV-2, which caused the …

SARS-CoV-2 ORF8: One protein, seemingly one structure, and many functions

S Vinjamuri, L Li, M Bouvier - Frontiers in immunology, 2022 - frontiersin.org
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. The genome of SARS-
CoV-2 encodes nine accessory proteins that are involved in host-pathogen interaction …

A review on structural, non-structural, and accessory proteins of SARS-CoV-2: Highlighting drug target sites

MJ Islam, NN Islam, MS Alom, M Kabir, MA Halim - Immunobiology, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, is a highly transmittable and pathogenic human coronavirus that first emerged in …

Alkyne as a Latent Warhead to Covalently Target SARS-CoV-2 Main Protease

C Ngo, W Fried, S Aliyari, J Feng, C Qin… - Journal of Medicinal …, 2023 - ACS Publications
There is an urgent need for improved therapy to better control the ongoing COVID-19
pandemic. The main protease Mpro plays a pivotal role in SARS-CoV-2 replications, thereby …

Cytokines and microRNAs in SARS-CoV-2: What do we know?

FZ Rarani, B Rashidi, MHJN Abadi, MR Hamblin… - … Therapy-Nucleic Acids, 2022 - cell.com
The coronavirus disease 2019 (COVID-19) pandemic constitutes a global health
emergency. Currently, there are no completely effective therapeutic medications for the …

The past, current and future epidemiological dynamic of SARS-CoV-2

F Balloux, C Tan, L Swadling, D Richard… - Oxford Open …, 2022 - academic.oup.com
Abstract SARS-CoV-2, the agent of the COVID-19 pandemic, emerged in late 2019 in China,
and rapidly spread throughout the world to reach all continents. As the virus expanded in its …

Ayurveda Rasayana as antivirals and immunomodulators: potential applications in COVID-19

R Singh, S Goel, P Bourgeade, L Aleya… - … Science and Pollution …, 2021 - Springer
Abstract Coronavirus disease (COVID-19) has been declared as a pandemic by the World
Health Organization with rapid spread across 216 countries. COVID-19 pandemic has left its …