Research and practice in critical care medicine have long been defined by syndromes,
which, despite being clinically recognizable entities, are, in fact, loose amalgams of …

We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …

Abstract Treatment with immune checkpoint blockade (ICB) frequently triggers immune-
related adverse events (irAEs), causing considerable morbidity. In 214 patients receiving …

Regulatory variants are often context specific, modulating gene expression in a subset of
possible cellular states. Although these genetic effects can play important roles in disease …

A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data
sets to construct predictive models of IBD. We present a predictive model of the immune …

The immune system plays a major role in human health and disease, and understanding
genetic causes of interindividual variability of immune responses is vital. Here, we isolate …

Background DNA methylation is influenced by both environmental and genetic factors and is
increasingly thought to affect variation in complex traits and diseases. Yet, the extent of …

The toll‐like receptor (TLR) family consists of vital receptors responsible for pattern
recognition in innate immunity, making them the core proteins involved in pathogen …

Neutrophils form the most abundant leukocyte subset and are central to many disease
processes. Technical challenges in transcriptomic profiling have prohibited genomic …

Background Exposure to traffic-related air pollution (TRAP) is associated with accelerated
cognitive aging and higher dementia risk in human populations. Rodent brains respond to …