Inflammatory bowel disease (IBD) is an umbrella term for the chronic immune-mediated
idiopathic inflammation of the gastrointestinal tract, manifesting as Crohn's disease (CD) or …

Cytokines are small proteins that are secreted by a vast majority of cell types in the gut. They
not only establish cell-to-cell interactions and facilitate cellular signaling, but also regulate …

Innate lymphoid cells (ILCs) are important for mucosal immunity. The intestine harbors all
ILC subsets, but how these cells are balanced to achieve immune homeostasis and mount …

Altered microenvironmental stiffness is a hallmark of inflammation. It is sensed by the
mechanically activated cation channel Piezo1 in macrophages to induce subsequent …

Cytokines play an important role in the immunopathogenesis of inflammatory bowel disease
(IBD), including Crohn's disease and ulcerative colitis, where they drive and regulate …

The hallmarks of inflammatory bowel disease are mucosal damage and ulceration, which
are known to be high-risk conditions for the development of colorectal cancer. Recently …

Abstract Interleukin-33 (IL-33) is a member of the IL-1 cytokine family that has been widely
studied since its discovery in 2005 for its dichotomous functions in homeostasis and …

The gut is the largest producer of serotonin or 5-hydroxytryptamine (5-HT) in the human
body, and 5-HT has been recognized as an important signaling molecule in the gut for …

Chemotherapy-induced nausea and vomiting (CINV) is a common side effect of patients with
cancer receiving chemotherapeutic drugs. However, the pathological mechanism of CINV is …

Intestinal diseases have always posed a serious threat to human health, with inflammatory
bowel disease (IBD) being one of them. IBD is an autoimmune disease characterized by …