Wall teichoic acids of gram-positive bacteria
S Brown, JP Santa Maria Jr… - Annual review of …, 2013 - annualreviews.org
The peptidoglycan layers of many gram-positive bacteria are densely functionalized with
anionic glycopolymers known as wall teichoic acids (WTAs). These polymers play crucial …
anionic glycopolymers known as wall teichoic acids (WTAs). These polymers play crucial …
The action mechanism of daptomycin
SD Taylor, M Palmer - Bioorganic & medicinal chemistry, 2016 - Elsevier
Daptomycin is a lipopeptide antibiotic produced by the soil bacterium Streptomyces
roseosporus that is clinically used to treat severe infections with Gram-positive bacteria. In …
roseosporus that is clinically used to treat severe infections with Gram-positive bacteria. In …
Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids
F Grein, A Müller, KM Scherer, X Liu, KC Ludwig… - Nature …, 2020 - nature.com
The lipopeptide daptomycin is used as an antibiotic to treat severe infections with gram-
positive pathogens, such as methicillin resistant Staphylococcus aureus (MRSA) and drug …
positive pathogens, such as methicillin resistant Staphylococcus aureus (MRSA) and drug …
Structural diversity, biosynthesis, and biological functions of lipopeptides from Streptomyces
S Zhang, Y Chen, J Zhu, Q Lu, MJ Cryle… - Natural Product …, 2023 - pubs.rsc.org
Covering: up to 2022 Streptomyces are ubiquitous in terrestrial and marine environments,
where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific …
where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific …
Daptomycin-mediated reorganization of membrane architecture causes mislocalization of essential cell division proteins
J Pogliano, N Pogliano, JA Silverman - Journal of bacteriology, 2012 - Am Soc Microbiol
Daptomycin is a lipopeptide antibiotic used clinically for the treatment of certain types of
Gram-positive infections, including those caused by methicillin-resistant Staphylococcus …
Gram-positive infections, including those caused by methicillin-resistant Staphylococcus …
Undecaprenyl phosphate translocases confer conditional microbial fitness
The microbial cell wall is essential for maintenance of cell shape and resistance to external
stressors. The primary structural component of the cell wall is peptidoglycan, a glycopolymer …
stressors. The primary structural component of the cell wall is peptidoglycan, a glycopolymer …
More than a pore: a current perspective on the in vivo mode of action of the lipopeptide antibiotic daptomycin
DA Gray, M Wenzel - Antibiotics, 2020 - mdpi.com
Daptomycin is a cyclic lipopeptide antibiotic, which was discovered in 1987 and entered the
market in 2003. To date, it serves as last resort antibiotic to treat complicated skin infections …
market in 2003. To date, it serves as last resort antibiotic to treat complicated skin infections …
Two broadly conserved families of polyprenyl-phosphate transporters
IJ Roney, DZ Rudner - Nature, 2023 - nature.com
Peptidoglycan and almost all surface glycopolymers in bacteria are built in the cytoplasm on
the lipid carrier undecaprenyl phosphate (UndP),,–. These UndP-linked precursors are …
the lipid carrier undecaprenyl phosphate (UndP),,–. These UndP-linked precursors are …
Lipopeptides in microbial infection control: scope and reality for industry
Lipopeptides are compounds that are formed by cyclic or short linear peptides linked with a
lipid tail or other lipophilic molecules. Recently, several lipopeptides were characterized …
lipid tail or other lipophilic molecules. Recently, several lipopeptides were characterized …
Cadasides, calcium-dependent acidic lipopeptides from the soil metagenome that are active against multidrug-resistant bacteria
The growing threat of antibiotic resistance necessitates the discovery of antibiotics that are
active against resistant pathogens. Calcium-dependent antibiotics are a small family of …
active against resistant pathogens. Calcium-dependent antibiotics are a small family of …