The peptidoglycan layers of many gram-positive bacteria are densely functionalized with
anionic glycopolymers known as wall teichoic acids (WTAs). These polymers play crucial …

Daptomycin is a lipopeptide antibiotic produced by the soil bacterium Streptomyces
roseosporus that is clinically used to treat severe infections with Gram-positive bacteria. In …

The lipopeptide daptomycin is used as an antibiotic to treat severe infections with gram-
positive pathogens, such as methicillin resistant Staphylococcus aureus (MRSA) and drug …

Covering: up to 2022 Streptomyces are ubiquitous in terrestrial and marine environments,
where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific …

Daptomycin is a lipopeptide antibiotic used clinically for the treatment of certain types of
Gram-positive infections, including those caused by methicillin-resistant Staphylococcus …

The microbial cell wall is essential for maintenance of cell shape and resistance to external
stressors. The primary structural component of the cell wall is peptidoglycan, a glycopolymer …

Daptomycin is a cyclic lipopeptide antibiotic, which was discovered in 1987 and entered the
market in 2003. To date, it serves as last resort antibiotic to treat complicated skin infections …

Peptidoglycan and almost all surface glycopolymers in bacteria are built in the cytoplasm on
the lipid carrier undecaprenyl phosphate (UndP),,–. These UndP-linked precursors are …

Lipopeptides are compounds that are formed by cyclic or short linear peptides linked with a
lipid tail or other lipophilic molecules. Recently, several lipopeptides were characterized …

The growing threat of antibiotic resistance necessitates the discovery of antibiotics that are
active against resistant pathogens. Calcium-dependent antibiotics are a small family of …