Glycosylation reactions mainly catalyzed by glycosyltransferases (Gts) occur almost
everywhere in the biosphere, and always play crucial roles in vital processes. In order to …

Covering: up to 2020 C-Glycosyltransferases are enzymes that catalyse the transfer of sugar
molecules to carbon atoms in substituted aromatic rings of a variety of natural products. The …

Glycosyltransferases have attracted increasing interest for the ability to construct
glycosylated molecules in a facile way. However, promiscuous chemoselectivity and poor …

Bioactive natural C-glycosides are rare and chemical C-glycosylation faces challenges
while enzymatic C-glycosylation catalyzed by C-glycosyltransferases provides an alternative …

The catalytic promiscuity of the novel benzophenone C‐glycosyltransferase, MiCGT, which
is involved in the biosynthesis of mangiferin from Mangifera indica, was explored. MiCGT …

Highlights•GTs are highly selective in nature.•Structural snapshots provided insights into the
catalytic mechanisms of GTs.•GTs have evolved a series of mechanisms to gain functionality …

A prominent attribute of chemical structure in microbial and plant natural products is
aromatic C-glycosylation. In plants, various flavonoid natural products have a β-Cd-glucosyl …

Family 1 glycosyltransferases (GT1s, UGTs) form natural product glycosides with exquisite
control over regio-and stereoselectivity, representing attractive biotechnological targets …

Microbes are talented chemists with the ability to generate tremendously complex and
diverse natural products which harbor potent biological activities. Natural products are …

C-Glycosyltransferases (CGTs) are powerful tools for the C-glycosylation of natural and
unnatural products. However, CGTs able to catalyze bis-C-glycosylation are very rare and …