Precision autophagy directed by receptor regulators–emerging examples within the TRIM family
Selective autophagy entails cooperation between target recognition and assembly of the
autophagic apparatus. Target recognition is conducted by receptors that often recognize …
autophagic apparatus. Target recognition is conducted by receptors that often recognize …
TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1
T Han, M Guo, M Gan, B Yu, X Tian, JB Wang - Autophagy, 2018 - Taylor & Francis
Macroautophagy/autophagy is a multistep cellular process that sequesters cytoplasmic
components for lysosomal degradation. BECN1/Beclin1 is a central protein that assembles …
components for lysosomal degradation. BECN1/Beclin1 is a central protein that assembles …
TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1
KS Overå, J Garcia-Garcia, Z Bhujabal… - Journal of cell …, 2019 - journals.biologists.com
The tripartite motif (TRIM) proteins constitute a family of ubiquitin E3 ligases involved in a
multitude of cellular processes, including protein homeostasis and autophagy. TRIM32 is …
multitude of cellular processes, including protein homeostasis and autophagy. TRIM32 is …