Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials
EE Patton, LI Zon, DM Langenau - Nature Reviews Drug Discovery, 2021 - nature.com
Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …
Zebrafish larvae as a behavioral model in neuropharmacology
Zebrafish larvae show a clear and distinct pattern of swimming in response to light and dark
conditions, following the development of a swim bladder at 4 days post fertilization. This …
conditions, following the development of a swim bladder at 4 days post fertilization. This …
[HTML][HTML] Toxicological effects of 6PPD and 6PPD quinone in zebrafish larvae
Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) is the most widely
used antioxidant in automobile tyres and many rubber products. We investigated the impact …
used antioxidant in automobile tyres and many rubber products. We investigated the impact …
Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics
Interfacing electronics with neural tissue is crucial for understanding complex biological
functions, but conventional bioelectronics consist of rigid electrodes fundamentally …
functions, but conventional bioelectronics consist of rigid electrodes fundamentally …
Acute toxic effects of polyethylene microplastic on adult zebrafish
CW Mak, KCF Yeung, KM Chan - Ecotoxicology and environmental safety, 2019 - Elsevier
To identify the physical effects, behavioral changes, and gene expression profiles of the
phase 1 detoxification-related gene (cyp 1a) and oogenesis-related gene (vtg 1) induced by …
phase 1 detoxification-related gene (cyp 1a) and oogenesis-related gene (vtg 1) induced by …
Zebrafish as an emerging model for studying complex brain disorders
AV Kalueff, AM Stewart, R Gerlai - Trends in pharmacological sciences, 2014 - cell.com
The zebrafish (Danio rerio) is rapidly becoming a popular model organism in
pharmacogenetics and neuropharmacology. Both larval and adult zebrafish are currently …
pharmacogenetics and neuropharmacology. Both larval and adult zebrafish are currently …
Zebrafish models for translational neuroscience research: from tank to bedside
The zebrafish (Danio rerio) is emerging as a new important species for studying
mechanisms of brain function and dysfunction. Focusing on selected central nervous system …
mechanisms of brain function and dysfunction. Focusing on selected central nervous system …
Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish
CD Kinch, K Ibhazehiebo, JH Jeong… - Proceedings of the …, 2015 - National Acad Sciences
Bisphenol A (BPA), a ubiquitous endocrine disruptor that is present in many household
products, has been linked to obesity, cancer, and, most relevant here, childhood …
products, has been linked to obesity, cancer, and, most relevant here, childhood …
Making waves: New developments in toxicology with the zebrafish
KA Horzmann, JL Freeman - Toxicological Sciences, 2018 - academic.oup.com
The laboratory zebrafish (Danio rerio) is now an accepted model in toxicologic research.
The zebrafish model fills a niche between in vitro models and mammalian biomedical …
The zebrafish model fills a niche between in vitro models and mammalian biomedical …
An end to the controversy over the microscopic detection and effects of pristine microplastics in fish organs
C De Sales-Ribeiro, Y Brito-Casillas, A Fernandez… - Scientific Reports, 2020 - nature.com
The aquatic environment and the associated fish assemblages are being exposed to an
increasing amount of microplastics. Despite the high number of publications on the …
increasing amount of microplastics. Despite the high number of publications on the …