The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

Tuberculosis (TB) remains a major health threat, killing nearly 2 million individuals around
this globe, annually. The only vaccine, developed almost a century ago, provides limited …

Pathogenic bacteria must withstand diverse host environments during infection.
Environmental signals, such as pH, temperature, nutrient limitation, etc., not only trigger …

Immunological tests provide evidence of latent tuberculosis in one third of the global
population, which corresponds to more than two billion individuals. Latent tuberculosis is …

Activation of the DNA-dependent cytosolic surveillance pathway in response to
Mycobacterium tuberculosis infection stimulates ubiquitin-dependent autophagy and …

Galleria mellonella (greater wax moth) larvae are used widely as surrogate infectious
disease models, due to ease of use and the presence of an innate immune system …

The aim of this review is to present the current state of knowledge on human latent
tuberculosis infection (LTBI) based on clinical studies and observations, as well as …

Infectious diseases caused by clinically important Mycobacteria continue to be an important
public health problem worldwide primarily due to emergence of drug resistance crisis. In …

Intracellular pathogens such as Mycobacterium tuberculosis have evolved strategies for
coping with the pressures encountered inside host cells. The ability to coordinate global …

Mycobacterium tuberculosis survives in latently infected individuals, likely in a
nonreplicating or dormancy-like state. The M. tuberculosis DosR regulon is a genetic …