[HTML][HTML] Hyperpolarized 13C MRI: path to clinical translation in oncology
This white paper discusses prospects for advancing hyperpolarization technology to better
understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13 C …
understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13 C …
Multiplexed imaging for diagnosis and therapy
Complex molecular and metabolic phenotypes depict cancers as a constellation of different
diseases with common themes. Precision imaging of such phenotypes requires flexible and …
diseases with common themes. Precision imaging of such phenotypes requires flexible and …
[HTML][HTML] Hybrid cardiac imaging using PET/MRI: a joint position statement by the European Society of Cardiovascular Radiology (ESCR) and the European …
Positron emission tomography (PET) and magnetic resonance imaging (MRI) have both
been used for decades in cardiovascular imaging. Since 2010, hybrid PET/MRI using …
been used for decades in cardiovascular imaging. Since 2010, hybrid PET/MRI using …
Hyperpolarized carbon 13 MRI: clinical applications and future directions in oncology
Hyperpolarized carbon 13 MRI (13C MRI) is a novel imaging approach that can
noninvasively probe tissue metabolism in both normal and pathologic tissues. The process …
noninvasively probe tissue metabolism in both normal and pathologic tissues. The process …
Hyperpolarized 13C Magnetic Resonance Imaging of Fumarate Metabolism by Parahydrogen‐induced Polarization: A Proof‐of‐Concept in vivo Study
NJ Stewart, H Nakano, S Sugai, M Tomohiro… - …, 2021 - Wiley Online Library
Abstract Hyperpolarized [1‐13C] fumarate is a promising magnetic resonance imaging (MRI)
biomarker for cellular necrosis, which plays an important role in various disease and …
biomarker for cellular necrosis, which plays an important role in various disease and …
[HTML][HTML] The use of dynamic nuclear polarization 13C-pyruvate MRS in cancer
In recent years there has been an immense development of new targeted anti-cancer drugs.
For practicing precision medicine, a sensitive method imaging for non-invasive, assessment …
For practicing precision medicine, a sensitive method imaging for non-invasive, assessment …
Dissolution DNP for in vivo preclinical studies
A Comment - Journal of Magnetic Resonance, 2016 - Elsevier
The tremendous polarization enhancement afforded by dissolution dynamic nuclear
polarization (DNP) can be taken advantage of to perform preclinical in vivo molecular and …
polarization (DNP) can be taken advantage of to perform preclinical in vivo molecular and …
Magnetic resonance imaging of cancer metabolism with hyperpolarized 13C-labeled cell metabolites
RL Hesketh, KM Brindle - Current opinion in chemical biology, 2018 - Elsevier
Highlights•Hyperpolarization of 13 C substrates by dissolution dynamic nuclear polarization
can increase NMR signal by> 10 4.•Many hyperpolarized substrates have been developed …
can increase NMR signal by> 10 4.•Many hyperpolarized substrates have been developed …
[HTML][HTML] Simultaneous characterization of tumor cellularity and the Warburg effect with PET, MRI and hyperpolarized 13C-MRSI
Modern oncology aims at patient-specific therapy approaches, which triggered the
development of biomedical imaging techniques to synergistically address tumor biology at …
development of biomedical imaging techniques to synergistically address tumor biology at …
[HTML][HTML] Metabolic contrast agents produced from transported solid 13C-glucose hyperpolarized via dynamic nuclear polarization
Abstract Magnetic Resonance Imaging combined with hyperpolarized 13C-labelled
metabolic contrast agents produced via dissolution Dynamic Nuclear Polarization can, non …
metabolic contrast agents produced via dissolution Dynamic Nuclear Polarization can, non …