Lysosomes are single membrane-bound organelles containing acid hydrolases responsible
for the degradation of cellular cargo and maintenance of cellular homeostasis. Lysosomes …

Amino acid transporters (AATs) are membrane-bound transport proteins that mediate
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …

Lysosomes are the primary degradative compartment within cells and there have been
significant advances over the past decade toward understanding how lysosome …

Tumor cells have an increased demand for amino acids because of their rapid proliferation
rate. In addition to their need in protein synthesis, several amino acids have other roles in …

Macroautophagy/autophagy is an essential, conserved self-eating process that cells perform
to allow degradation of intracellular components, including soluble proteins, aggregated …

Lysosomes are key cellular catabolic centers that also perform fundamental metabolic,
signaling and quality control functions. Lysosomes are not static and they respond …

Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are
highly dependent on nutrients in order to duplicate their cell mass during each cell division …

The demand for high-quality milk is increasing worldwide. The efficiency of milk synthesis
can be improved by taking advantage of the accumulated knowledge of the transcriptional …

SARS-CoV-2 vaccinations have greatly reduced COVID-19 cases, but we must continue to
develop our understanding of the nature of the disease and its effects on human immunity …

As glutamine plays a central role in cancer metabolism, inhibition of glutaminolysis has
become an ideal anticancer therapeutic target. However, glutaminolysis inhibition leads to …