Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics
L Migliore, F Coppedè - Nature Reviews Neurology, 2022 - nature.com
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …
A precision environmental health approach to prevention of human disease
Human health is determined by the interaction of our environment with the genome,
epigenome, and microbiome, which shape the transcriptomic, proteomic, and metabolomic …
epigenome, and microbiome, which shape the transcriptomic, proteomic, and metabolomic …
Health repercussions of environmental exposure to lead: Methylation perspective
SS Shiek, MS Mani, SP Kabekkodu, HS Dsouza - Toxicology, 2021 - Elsevier
Lead (Pb) exposure has been a major public health concern for a long time now due to its
permanent adverse effects on the human body. The process of lead toxicity has still not been …
permanent adverse effects on the human body. The process of lead toxicity has still not been …
Metals exposures and DNA methylation: current evidence and future directions
ER Elkin, C Higgins, MT Aung, KM Bakulski - Current environmental health …, 2022 - Springer
Abstract Purpose of the Review Exposure to essential and non-essential metals is
widespread. Metals exposure is linked to epigenetic, particularly DNA methylation …
widespread. Metals exposure is linked to epigenetic, particularly DNA methylation …
[HTML][HTML] A review on aquatic toxins-Do we really know it all regarding the environmental risk posed by phytoplankton neurotoxins?
Aquatic toxins are potent natural toxins produced by certain cyanobacteria and marine algae
species during harmful cyanobacterial and algal blooms (CyanoHABs and HABs …
species during harmful cyanobacterial and algal blooms (CyanoHABs and HABs …
piOxi database: a web resource of germline and somatic tissue piRNAs identified by chemical oxidation
PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that are highly
expressed and extensively studied from the germline. piRNAs associate with PIWI proteins …
expressed and extensively studied from the germline. piRNAs associate with PIWI proteins …
Influence of woodsmoke exposure on molecular mechanisms underlying Alzheimer's disease: Existing literature and gaps in our understanding
A Schuller, L Montrose - Epigenetics Insights, 2020 - journals.sagepub.com
Woodsmoke poses a significant health risk as a growing component of ambient air pollution
in the United States. While there is a long history of association between woodsmoke …
in the United States. While there is a long history of association between woodsmoke …
HeLa TI cell-based assay as a new approach to screen for chemicals able to reactivate the expression of epigenetically silenced genes
V Maksimova, N Shalginskikh, O Vlasova, O Usalka… - PLoS …, 2021 - journals.plos.org
Chemicals reactivating epigenetically silenced genes target diverse classes of enzymes,
including DNMTs, HDACs, HMTs and BET protein family members. They can strongly …
including DNMTs, HDACs, HMTs and BET protein family members. They can strongly …
Perinatal DEHP exposure induces sex-and tissue-specific DNA methylation changes in both juvenile and adult mice
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a type of phthalate plasticizer found in a
variety of consumer products and poses a public health concern due to its metabolic and …
variety of consumer products and poses a public health concern due to its metabolic and …
Circular RNAs in toxicology
Y Shao, Y Jiang - Toxicological Sciences, 2021 - academic.oup.com
Circular RNAs (circRNAs) are a type of closed, long, non-coding RNAs, which have attracted
significant attention in recent years. CircRNAs exhibit unique functions and are …
significant attention in recent years. CircRNAs exhibit unique functions and are …