Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …

Intratumour heterogeneity (ITH) is a hallmark of cancer that drives tumour evolution and
disease progression. Technological and computational advances have enabled us to …

Triple-negative breast cancer (TNBC) is an aggressive subtype associated with early
metastatic recurrence and worse patient outcomes. TNBC tumors express molecular …

Necrosis in the tumor interior is a common feature of aggressive cancers that is associated
with poor clinical prognosis and the development of metastasis. How the necrotic core …

Metastatic dissemination has lethal consequences for cancer patients. Accruing evidence
supports the hypothesis that tumor cells can migrate and metastasize as clusters of cells …

Simple Summary Tumour heterogeneity is a phenomenon where the cancer cells evolve
diversely over the course of the disease. As a result of the evolution, the cancer cells can be …

Collective cell movements drive normal development and metastasis. Drosophila border
cells move as a cluster of 6–10 cells, where the role of the Rac GTPase in migration was first …

The TFAP2 family regulates gene expression during differentiation, development, and
organogenesis, and includes five homologs in humans. They all possess a highly conserved …

Cancer cells exist in a complex ecosystem with numerous other cell types in the tumor
microenvironment (TME). The composition of this tumor/TME ecosystem will vary at each …

Metastasis is a multistep process by which cancer cells break away from their original
location and spread to distant organs, and is responsible for the vast majority of cancer …