The Eph receptors are the largest of the RTK families. Like other RTKs, they transduce
signals from the cell exterior to the interior through ligand-induced activation of their kinase …

Receptor tyrosine kinases of the Eph family bind to cell surface-associated ephrin ligands on
neighboring cells. The ensuing bidirectional signals have emerged as a major form of …

The regenerative capacity of injured adult mammalian central nervous system (CNS) tissue
is very limited. Disease or injury that causes destruction or damage to neuronal networks …

Adult CNS neurons are typically described as permanently postmitotic but there is probably
nothing permanent about the neuronal cell cycle arrest. Rather, it appears that these highly …

Ephrin ligands and their cognate Eph receptors guide axons during neural development and
regulate synapse formation and neuronal plasticity in the adult. Because ephrins are …

Cyclin-dependent kinase 5 (Cdk5) is a multifaceted serine/threonine kinase protein with
important roles in the nervous system. Two related proteins, p35 and p39, activate Cdk5 …

Synapses are specialized cell–cell contacts that mediate communication between neurons.
Most excitatory synapses in the brain are housed on dendritic spines, small actin-rich …

Astrocytes are critical participants in synapse development and function, but their role in
synaptic plasticity is unclear. Eph receptors and their ephrin ligands have been suggested to …

Bidirectional signaling has emerged as an important signature by which Ephs and ephrins
control biological functions. Eph/ephrin signaling participates in a wide spectrum of …

Alzheimer's disease (AD), characterized by cognitive decline, has emerged as a disease of
synaptic failure. The present study reveals an unanticipated role of erythropoietin-producing …