Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima in which the
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …

Hypertension is a major risk factor for many common chronic diseases, such as heart failure,
myocardial infarction, stroke, vascular dementia, and chronic kidney disease …

Guzik and Touyz Oxidation and Inflammation in Vascular Aging 661 and endothelium. 22
Perivascular fibrosis is greatly dependent on immune cells because it is prevented in …

The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Metabolic syndrome is a global public health problem and predisposes individuals to
obesity, diabetes and cardiovascular disease. Although the underlying mechanisms remain …

Aging is the primary risk factor underlying hypertension and incident cardiovascular disease.
With aging, the vasculature undergoes structural and functional changes characterized by …

Aging can be seen as process characterized by accumulation of oxidative stress induced
damage. Oxidative stress derives from different endogenous and exogenous processes, all …

It is well established that adipose tissue, apart from its energy storage function, acts as an
endocrine organ that produces and secretes a number of bioactive substances, including …

Diabetes mellitus is associated with cognitive impairment characterized by memory loss and
cognitive inflexibility. Recent studies have revealed that ChemR23 is implicated in both …