Co‐shared genetics and possible risk gene pathway partially explain the comorbidity of schizophrenia, major depressive disorder, type 2 diabetes, and metabolic …

TT Postolache, L del Bosque‐Plata… - American Journal of …, 2019 - Wiley Online Library
Schizophrenia (SCZ) and major depressive disorder (MDD) in treatment‐naive patients are
associated with increased risk for type 2 diabetes (T2D) and metabolic syndrome (MetS) …

Unravelling the genetic basis of schizophrenia and bipolar disorder with GWAS: A systematic review

DP Prata, B Costa-Neves, G Cosme… - Journal of psychiatric …, 2019 - Elsevier
Objectives To systematically review findings of GWAS in schizophrenia (SZ) and in bipolar
disorder (BD); and to interpret findings, with a focus on identifying independent replications …

Genome-wide association studies: findings at the major histocompatibility complex locus in psychosis

A Corvin, DW Morris - Biological psychiatry, 2014 - Elsevier
The major histocompatibility complex (MHC) is one of the most intensively investigated,
genetically diverse regions of the genome. In its extended form, it encodes more than 400 …

Interleukin‐6 promoter polymorphism and plasma levels in patients with schizophrenia

R Zakharyan, M Petrek, A Arakelyan, F Mrazek… - Tissue …, 2012 - Wiley Online Library
Schizophrenia is a severe psychiatric disease with inflammatory component. Several studies
indicated the increased blood levels of proinflammatory interleukin‐6 cytokine in …

[HTML][HTML] Pro-inflammatory cytokines and their epistatic interactions in genetic susceptibility to schizophrenia

L Srinivas, NN Vellichirammal, AM Alex, C Nair… - Journal of …, 2016 - Springer
Background In schizophrenia, genetic background may provide a substrate for intrinsic
maldevelopment of the brain through environmental influences, by recruiting neurotrophic …

[HTML][HTML] Association of the Type 2 Diabetes Mellitus Susceptibility Gene, TCF7L2, with Schizophrenia in an Arab-Israeli Family Sample

A Alkelai, L Greenbaum, S Lupoli, Y Kohn… - PloS one, 2012 - journals.plos.org
Many reports in different populations have demonstrated linkage of the 10q24–q26 region to
schizophrenia, thus encouraging further analysis of this locus for detection of specific …

New approaches to the management of schizophrenia: focus on aberrant hippocampal drive of dopamine pathways

SM Perez, DJ Lodge - Drug design, development and therapy, 2014 - Taylor & Francis
Schizophrenia is a disease affecting up to 1% of the population. Current therapies are based
on the efficacy of chlorpromazine, discovered over 50 years ago. These drugs block …

Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene

XJ Luo, M Li, L Huang, S Steinberg, M Mattheisen… - Molecular …, 2014 - nature.com
Genes that are differentially expressed between schizophrenia patients and healthy controls
may have key roles in the pathogenesis of schizophrenia. We analyzed two large-scale …

A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation

WTCC Consortium… - Biological …, 2014 - Elsevier
Background Genome-wide association studies (GWAS) have identified several loci
associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis …

Multivariate analysis of genome-wide data to identify potential pleiotropic genes for five major psychiatric disorders using MetaCCA

XC Jia, YL Yang, YC Chen, ZW Cheng, Y Du… - Journal of affective …, 2019 - Elsevier
Background: Genome-wide association studies have been extensively applied in identifying
SNP associated with major psychiatric disorders. However, the SNPs identified by the …