Co‐shared genetics and possible risk gene pathway partially explain the comorbidity of schizophrenia, major depressive disorder, type 2 diabetes, and metabolic …
TT Postolache, L del Bosque‐Plata… - American Journal of …, 2019 - Wiley Online Library
Schizophrenia (SCZ) and major depressive disorder (MDD) in treatment‐naive patients are
associated with increased risk for type 2 diabetes (T2D) and metabolic syndrome (MetS) …
associated with increased risk for type 2 diabetes (T2D) and metabolic syndrome (MetS) …
Unravelling the genetic basis of schizophrenia and bipolar disorder with GWAS: A systematic review
Objectives To systematically review findings of GWAS in schizophrenia (SZ) and in bipolar
disorder (BD); and to interpret findings, with a focus on identifying independent replications …
disorder (BD); and to interpret findings, with a focus on identifying independent replications …
Genome-wide association studies: findings at the major histocompatibility complex locus in psychosis
The major histocompatibility complex (MHC) is one of the most intensively investigated,
genetically diverse regions of the genome. In its extended form, it encodes more than 400 …
genetically diverse regions of the genome. In its extended form, it encodes more than 400 …
Interleukin‐6 promoter polymorphism and plasma levels in patients with schizophrenia
R Zakharyan, M Petrek, A Arakelyan, F Mrazek… - Tissue …, 2012 - Wiley Online Library
Schizophrenia is a severe psychiatric disease with inflammatory component. Several studies
indicated the increased blood levels of proinflammatory interleukin‐6 cytokine in …
indicated the increased blood levels of proinflammatory interleukin‐6 cytokine in …
[HTML][HTML] Pro-inflammatory cytokines and their epistatic interactions in genetic susceptibility to schizophrenia
Background In schizophrenia, genetic background may provide a substrate for intrinsic
maldevelopment of the brain through environmental influences, by recruiting neurotrophic …
maldevelopment of the brain through environmental influences, by recruiting neurotrophic …
[HTML][HTML] Association of the Type 2 Diabetes Mellitus Susceptibility Gene, TCF7L2, with Schizophrenia in an Arab-Israeli Family Sample
A Alkelai, L Greenbaum, S Lupoli, Y Kohn… - PloS one, 2012 - journals.plos.org
Many reports in different populations have demonstrated linkage of the 10q24–q26 region to
schizophrenia, thus encouraging further analysis of this locus for detection of specific …
schizophrenia, thus encouraging further analysis of this locus for detection of specific …
New approaches to the management of schizophrenia: focus on aberrant hippocampal drive of dopamine pathways
Schizophrenia is a disease affecting up to 1% of the population. Current therapies are based
on the efficacy of chlorpromazine, discovered over 50 years ago. These drugs block …
on the efficacy of chlorpromazine, discovered over 50 years ago. These drugs block …
Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene
Genes that are differentially expressed between schizophrenia patients and healthy controls
may have key roles in the pathogenesis of schizophrenia. We analyzed two large-scale …
may have key roles in the pathogenesis of schizophrenia. We analyzed two large-scale …
A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation
WTCC Consortium… - Biological …, 2014 - Elsevier
Background Genome-wide association studies (GWAS) have identified several loci
associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis …
associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis …
Multivariate analysis of genome-wide data to identify potential pleiotropic genes for five major psychiatric disorders using MetaCCA
XC Jia, YL Yang, YC Chen, ZW Cheng, Y Du… - Journal of affective …, 2019 - Elsevier
Background: Genome-wide association studies have been extensively applied in identifying
SNP associated with major psychiatric disorders. However, the SNPs identified by the …
SNP associated with major psychiatric disorders. However, the SNPs identified by the …