Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …

Highlights (AQPs) are transmembrane proteins responsible for fast water movement across
cell membranes, including those of astrocytes. The expression and subcellular localization …

Gut microbiota has an important role in the immune system, metabolism, and digestion, and
has a significant effect on the nervous system. Recent studies have revealed that abnormal …

Epilepsy is a group of chronic neurological disorders characterized by recurrent,
spontaneous, and unpredictable seizures. It is one of the most common neurological …

Astrocytes regulate extracellular glutamate and water homeostasis through the astrocyte-
specific membrane proteins glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) …

Since the discovery of aquaporins, it has become clear that the various mammalian
aquaporins play critical physiological roles in water and ion balance in multiple tissues …

Recent studies have implicated glial cells in modulation of synaptic transmission, so it is
plausible that glial cells may have a functional role in the hyperexcitability characteristic of …

Abstract Changes in astrocyte channels, transporters, and metabolism play a critical role in
seizure generation and epilepsy. In particular, alterations in astrocyte potassium, glutamate …

Three aquaporins are expressed in the brain. AQP4, the predominant brain water channel,
is expressed in astrocyte endfeet facing brain capillaries, perisynaptic spaces, and nodes of …

The family of aquaporins (AQPs), membrane water channels, consists of diverse types of
proteins that are mainly permeable to water; some are also permeable to small solutes, such …