Sarcoidosis is a systemic disease of unknown etiology defined by the presence of
noncaseating granulomatous inflammation that can cause organ damage and diminished …

Since sarcoidosis was first described more than a century ago, the etiologic determinants
causing this disease remain uncertain. Studies suggest that genetic, host immunologic, and …

Sarcoidosis is an enigmatic multisystem disease characterized by the development and
accumulation of granulomas: a compact collection of macrophages that have differentiated …

Granulomas are clusters of immune cells. These structures can be formed in reaction to
infection and display signs of necrosis, such as in tuberculosis. Alternatively, in several …

Sarcoidosis pathogenesis is characterized by peripheral anergy and an exaggerated,
pulmonary CD4+ Th1 response. In this study, we demonstrate that CD4+ anergic responses …

Sarcoidosis is a systemic inflammatory disease characterized by development of
granulomas in the affected organs. Sarcoidosis is often a diagnosis of exclusion, and …

This manuscript outlines recent advances in the diagnosis and treatment of sarcoidosis. The
diagnosis of sarcoidosis can occasionally be made on clinical grounds without a …

Background Sarcoidosis is an idiopathic, granulomatous disease for which molecular and
immunologic studies have shown an association between it and mycobacterial antigens …

The presence of hypergammaglobulinemia, autoantibodies, and circulating immune
complexes suggests that humoral immunity may contribute to the pathogenesis of …

In the light of the Matzinger's model of immune response, human heat shock proteins (HSPs)
as main 'danger signals'(tissue damage-associated molecular patterns-DAMPs) or/and …