Abstract The Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census
(CGC) is an expert-curated description of the genes driving human cancer that is used as a …

Next‐generation sequencing methods have revolutionized the speed of generating variation
information. Sequence data have a plethora of applications and will increasingly be used for …

Understanding the profile of oncogene and tumor suppressor gene mutations with their
interactions and impact on the prognosis of multiple myeloma (MM) can improve the …

Current statistical models for assessing hotspot significance do not properly account for
variation in site-specific mutability, thereby yielding many false-positives. We thus (i) detail a …

We previously presented DriverDB, a database that incorporates∼ 6000 cases of exome-
seq data, in addition to annotation databases and published bioinformatics algorithms …

Understanding genetic events that lead to cancer initiation and progression remains one of
the biggest challenges in cancer biology. Traditionally, most algorithms for cancer-driver …

Background Lung cancer is the leading cause of the largest number of deaths worldwide
and lung adenocarcinoma is the most common form of lung cancer. In order to understand …

Breast cancer is the second most frequently occurring form of cancer and is also the second
most lethal cancer in women worldwide. A genetic mutation is one of the key factors that …

Objective There are few studies which characterised the molecular alterations in
premalignant colorectal adenomas. Our major goal was to establish colorectal adenoma …

Lung cancer is the second most frequently diagnosed cancer type and responsible for the
highest number of cancer deaths worldwide. Lung adenocarcinoma (LUAD) and lung …