The DNA methylation landscape in cancer
As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …
plays an essential role in normal development and cellular biology. Global alterations to the …
Functions and mechanisms of epigenetic inheritance in animals
The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …
RNA can be passed to the next generation through meiotic products (gametes) is long …
Multi-omics profiling of mouse gastrulation at single-cell resolution
Formation of the three primary germ layers during gastrulation is an essential step in the
establishment of the vertebrate body plan and is associated with major transcriptional …
establishment of the vertebrate body plan and is associated with major transcriptional …
[HTML][HTML] Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
Background DNA methylation is one of the main epigenetic mechanisms for the regulation of
gene expression in eukaryotes. In the standard model, methylation in gene promoters has …
gene expression in eukaryotes. In the standard model, methylation in gene promoters has …
[HTML][HTML] Amphioxus functional genomics and the origins of vertebrate gene regulation
Vertebrates have greatly elaborated the basic chordate body plan and evolved highly
distinctive genomes that have been sculpted by two whole-genome duplications. Here we …
distinctive genomes that have been sculpted by two whole-genome duplications. Here we …
[HTML][HTML] Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements
Zebrafish, a popular organism for studying embryonic development and for modeling human
diseases, has so far lacked a systematic functional annotation program akin to those in other …
diseases, has so far lacked a systematic functional annotation program akin to those in other …
[HTML][HTML] The little skate genome and the evolutionary emergence of wing-like fins
F Marlétaz, E de la Calle-Mustienes, RD Acemel… - Nature, 2023 - nature.com
Skates are cartilaginous fish whose body plan features enlarged wing-like pectoral fins,
enabling them to thrive in benthic environments,. However, the molecular underpinnings of …
enabling them to thrive in benthic environments,. However, the molecular underpinnings of …
[HTML][HTML] Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo
R Gilsbach, M Schwaderer, S Preissl… - Nature …, 2018 - nature.com
Epigenetic mechanisms and transcription factor networks essential for differentiation of
cardiac myocytes have been uncovered. However, reshaping of the epigenome of these …
cardiac myocytes have been uncovered. However, reshaping of the epigenome of these …
Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness
T Pachano, V Sánchez-Gaya, T Ealo, M Mariner-Faulí… - Nature …, 2021 - nature.com
CpG islands (CGIs) represent a widespread feature of vertebrate genomes, being
associated with~ 70% of all gene promoters. CGIs control transcription initiation by …
associated with~ 70% of all gene promoters. CGIs control transcription initiation by …
Enhancer DNA methylation: implications for gene regulation
A Angeloni, O Bogdanovic - Essays in biochemistry, 2019 - portlandpress.com
DNA methylation involves the addition of a methyl group to the fifth carbon of the pyrimidine
cytosine ring (5-methylcytosine, 5mC). 5mC is widespread in vertebrate genomes where it is …
cytosine ring (5-methylcytosine, 5mC). 5mC is widespread in vertebrate genomes where it is …