The classification of tumours of the pituitary gland has recently been revised in the 2021 5th
edition World Health Organization (WHO) Classification of Central Nervous System Tumours …

Plurihormonal pituitary adenoma (PPA) is a type of pituitary tumor capable of producing two
or more hormones and usually presents as an aggressive, large adenoma. As yet, its …

As a typical E3 ligase, TRIM65 (tripartite motif containing 65) is involved in the regulation of
antiviral innate immunity and the pathogenesis of certain tumors. However, the role of …

Medulloblastoma (MB) is a prevalent malignant brain tumor among children, which can be
classified into four primary molecular subgroups. Group 3 MB (G3-MB) is known to be highly …

Abstract Background Pituitary neuroendocrine tumors (PitNETs) are common gland
neoplasms demonstrating distinctive transcription factors. Although the role of immune cells …

Abstract The Ly-6 and uPAR (LU) domain-containing proteins represent a large family of cell-
surface markers. In particular, mouse Ly-6A/Sca-1 is a widely used marker for various stem …

We aimed to identify the druggable cell-intrinsic vulnerabilities and target-based drug
therapies for PitNETs using the high-throughput drug screening (HTS) and genomic …

Our previous research suggests that targeting NLRP3 inflammasomes holds promise for
mitigating cerebral ischemia/reperfusion injury. The gut metabolite Urolithin B (UroB) has …

Background and aims Tripartite motif (TRIM65) is an important member of the TRIM protein
family, which is a newly discovered E 3 ligase that interacts with and ubiquitinates various …

Purpose The dopamine agonists (DA) have been used widely to treat prolactinomas.
However, it is difficult to predict whether the patient will be responsive to DA treatment …