Tuberculous meningitis

RJ Wilkinson, U Rohlwink, UK Misra… - Nature reviews …, 2017 - nature.com
Tuberculosis remains a global health problem, with an estimated 10.4 million cases and 1.8
million deaths resulting from the disease in 2015. The most lethal and disabling form of …

Corticosteroids for managing tuberculous meningitis

K Prasad, MB Singh, H Ryan - Cochrane Database of …, 2016 - cochranelibrary.com
Background Tuberculous meningitis is a serious form of tuberculosis (TB) that affects the
meninges that cover a person's brain and spinal cord. It is associated with high death rates …

The pathogenesis of tuberculous meningitis

AG Davis, UK Rohlwink, A Proust… - Journal of leukocyte …, 2019 - academic.oup.com
Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the
brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM) …

[HTML][HTML] The current global situation for tuberculous meningitis: epidemiology, diagnostics, treatment and outcomes

JA Seddon, L Tugume, R Solomons… - Wellcome open …, 2019 - ncbi.nlm.nih.gov
Tuberculous meningitis (TBM) results from dissemination of M. tuberculosis to the
cerebrospinal fluid (CSF) and meninges. Ischaemia, hydrocephalus and raised intracranial …

Effectiveness of adjunctive high-dose infliximab therapy to improve disability-free survival among patients with severe central nervous system tuberculosis: a matched …

A Manesh, P Gautam, SS Kumar D… - Clinical Infectious …, 2023 - academic.oup.com
Background Few treatment options exist for patients with severe central nervous system
(CNS) tuberculosis (TB) worsening due to inflammatory lesions, despite optimal …

Treatment of tuberculous meningitis and its complications in adults

A Davis, G Meintjes, RJ Wilkinson - Current treatment options in neurology, 2018 - Springer
Purpose of review Tuberculous meningitis (TBM) is a global health problem. In this review,
we systematically evaluate the evidence for current and emerging antimicrobials, host …

Extrapulmonary tuberculosis

SK Sharma, A Mohan, M Kohli - Expert review of respiratory …, 2021 - Taylor & Francis
Introduction: Tuberculosis (TB) is a major cause of morbidity and mortality globally.
Extrapulmonary TB (EPTB) constitutes about 15%–20% of all TB patients, but accounts for …

The use of TNF-α antagonists in tuberculosis to control severe paradoxical reaction or immune reconstitution inflammatory syndrome: a case series and literature …

L Armange, A Lacroix, P Petitgas, C Arvieux… - European Journal of …, 2023 - Springer
Paradoxical reaction (PR) and immune reconstitution inflammatory syndrome (IRIS) are
common complications of tuberculosis treatment. Corticosteroids are first-line treatment for …

Use of infliximab to treat paradoxical tuberculous meningitis reactions

BJ Marais, E Cheong, S Fernando… - Open forum …, 2021 - academic.oup.com
We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with
severe paradoxical reactions after effective antibacterial treatment, despite high-dose …

[HTML][HTML] (Re-) introduction of TNF antagonists and JAK inhibitors in patients with previous tuberculosis: a systematic review

TT Brehm, M Reimann, N Köhler, C Lange - Clinical Microbiology and …, 2024 - Elsevier
Background Tuberculosis (TB) is a common complication associated with treatment with
tumour necrosis factor (TNF) antagonists and Janus kinase (JAK) inhibitors. However, there …