Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Abstract Activated B-cell (ABC)-diffuse large B-cell lymphomas (DLBCLs) are clinically
aggressive and phenotypically complex malignancies, whose transformation mechanisms …

The most aggressive B cell lymphomas frequently manifest extranodal distribution and carry
somatic mutations in the poorly characterized gene TBL1XR1. Here, we show that TBL1XR1 …

The microbially-derived short-chain fatty acid butyrate is a central inhibitor of inflammatory
innate and adaptive immune responses. Emerging evidence suggests that butyrate induces …

The nuclear corepressors NCOR1 and NCOR2 interact with transcription factors involved in
B cell development and potentially link these factors to alterations in chromatin structure and …

B cells play a pivotal role in the pathogenesis of autoimmune diseases. Although previous
studies have shown many genetic polymorphisms associated with B-cell activation in …

Gliomas are the most common and aggressive malignancies of the central nervous system.
Histone deacetylases (HDACs) are important targets in cancer treatment. They regulate …

Purpose: Current melphalan-based regimens for intravitreal chemotherapy for
retinoblastoma vitreous seeds are effective but toxic to the retina. Thus, alternative agents …

In response to T-cell-dependent antigens, antigen-experienced B cells migrate to the center
of the B-cell follicle to seed the germinal center (GC) response after cognate interactions …

Transcriptional dysregulation is a hallmark of diffuse large B cell lymphoma (DLBCL), as
transcriptional regulators are frequently mutated. However, our mechanistic understanding …