This review discusses the current understanding of cysteine and glutathione redox balance
in astrocytes. Particular emphasis is placed on the impact of oxidative stress and astrocyte …

There are numerous theories of aging, a process which still seems inevitable. Aging leads to
cancer and multi-systemic disorders as well as chronic diseases. Decline in age-associated …

Homocysteine, an amino acid containing a sulfhydryl group, is an intermediate product
during metabolism of the amino acids methionine and cysteine. Hyperhomocysteinemia is …

Astrocytes are functionally diverse glial cells that maintain blood-brain barrier (BBB)
integrity, provide metabolic and trophic support, and react to pathogens or harmful stimuli …

Neuro-inflammation plays a critical role in hyperhomocysteinemia (HHcy)-associated
neurodegenerative disorders. Hydrogen sulfide (H 2 S) has been suggested as an …

Maternal hyperhomocysteinemia is one of the common complications of pregnancy that
causes offspring cognitive deficits during postnatal development. In this study, we …

Abstract The Cu/Zn− superoxide dismutase (SOD1) is a ubiquitous enzyme that catalyzes
the dismutation of superoxide radicals to oxygen and hydrogen peroxide. In addition to this …

Astrocytes may undergo a functional remodeling with aging, acquiring a pro-inflammatory
state. In line with this, resveratrol represents an interesting strategy for a healthier brain …

The aim of this study was to evaluate the immune-inflammatory, metabolic, and nitro-
oxidative stress (IM&NO) biomarkers as predictors of disability in multiple sclerosis (MS) …

The transsulfuration pathway (TSP) is a metabolic pathway involving sulfur transfer from
homocysteine to cysteine. Transsulfuration pathway leads to many sulfur metabolites …