Prebiotic peptides: Molecular hubs in the origin of life

M Frenkel-Pinter, M Samanta, G Ashkenasy… - Chemical …, 2020 - ACS Publications
The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

From dynamic self-assembly to networked chemical systems

BA Grzybowski, K Fitzner, J Paczesny… - Chemical Society …, 2017 - pubs.rsc.org
Although dynamic self-assembly, DySA, is a relatively new area of research, the past
decade has brought numerous demonstrations of how various types of components–on …

Self-reproducing catalytic micelles as nanoscopic protocell precursors

A Kahana, D Lancet - Nature Reviews Chemistry, 2021 - nature.com
Protocells at life's origin are often conceived as bilayer-enclosed precursors of life, whose
self-reproduction rests on the early advent of replicating catalytic biopolymers. This …

Supramolecular chemistry in lipid bilayer membranes

LE Bickerton, TG Johnson, A Kerckhoffs… - Chemical Science, 2021 - pubs.rsc.org
Lipid bilayer membranes form compartments requisite for life. Interfacing supramolecular
systems, including receptors, catalysts, signal transducers and ion transporters, enables the …

Nanoreactors: small spaces, big implications in chemistry

SH Petrosko, R Johnson, H White… - Journal of the American …, 2016 - ACS Publications
In recent years, chemists have worked to understand how fundamental chemical principles
change when systems are confined to spaces with nanoscale dimensions or sub-microliter …

Prebiotic systems chemistry: complexity overcoming clutter

S Islam, MW Powner - Chem, 2017 - cell.com
Living organisms are the most complex chemical system known to exist, yet they exploit only
a small constellation of universally conserved metabolites to support indefinite evolution …

Soft and dispersed interface-rich aqueous systems that promote and guide chemical reactions

S Serrano-Luginbühl, K Ruiz-Mirazo… - Nature reviews …, 2018 - nature.com
Although aqueous solutions are considered to be sustainable, environmentally friendly
reaction media, their use is often limited by poor reactant solubility. This limitation can be …

In situ quantitative single-molecule study of dynamic catalytic processes in nanoconfinement

B Dong, Y Pei, F Zhao, TW Goh, Z Qi, C Xiao, K Chen… - Nature Catalysis, 2018 - nature.com
Understanding the fundamental catalytic principles when the catalytic centre is confined in
nanoscale space that is dimensionally comparable to the reactant molecule is crucial for …

Copying of mixed-sequence RNA templates inside model protocells

DK O'Flaherty, NP Kamat, FN Mirza, L Li… - Journal of the …, 2018 - ACS Publications
The chemical replication of RNA inside fatty acid vesicles is a plausible step in the
emergence of cellular life. On the primitive Earth, simple protocells with the ability to import …

Zr-based MOFs shielded with phospholipid bilayers: improved biostability and cell uptake for biological applications

J Yang, X Chen, Y Li, Q Zhuang, P Liu… - Chemistry of …, 2017 - ACS Publications
For practical biomedical applications, the stabilization of nanoscale metal–organic
frameworks (NMOFs) in the presence of phosphate is of prime importance but remains a …