Acridine derivatives constitute a class of compounds that are being intensively studied as
potential anticancer drugs. Acridines are well-known for their high cytotoxic activity; …

Summary 1 lntroducuon 2 Classification and physlcochemlcal properties of acridines 2 1 9-
Anunoacndme and related compounds 2 2 Proflavme and related compounds 2 3 …

HeLa S 3 cells exposed to Adriamycin® and Daunomycin® for 3 hr at EC 90 and 10× EC 90
concentrations and incubated in drug-free medium demonstrated the characteristics of …

Cancer is one of the most formidable diseases of the world. In fact, if there is any disease
which the mankind is still most afraid of it is cancer. Cancer is not one disease, but a group …

Topoisomerase inhibitors have been in use clinically for the treatment of several diseases
for decades. Although those enzymes are significant molecular targets in antibacterial and …

Abstract Acridines/acridones, quinolines/quinolones (chromophores) and their derivatives
constitute extremely important family of compounds in current medicine. Great significance …

Using a new mild method it is shown for two anthracyclines, Adriamycin® and Daunomycin,
that these compounds are able to form DNA crosslinks in HeLa S 3 cells. It was also found …

The nitroacridine derivative 9-[[3-(dimethylamino) propyl] amino]-1-nitroacridine (nitracrine)
is selectively cytotoxic to hypoxic tumor cells in culture. However, the compound undergoes …

The synthesis of two groups (Chart 1, types A and B) of conjugates of MDP
(muramyldipeptide) and nor-MDP (normuramyldipeptide) with acridine/acridone derivatives …

A series of MDP (muramyldipeptide) or nor-MDP (normuramyldipeptide) analogues modified
at the C-terminus post of the molecule by a formation of an ester bond between the …