Most pharmaceutical products are manufactured either by applying a total synthesis
approach or by modifying a naturally occurring product. In both cases, a wide range of …

The human body is amazingly chirally selective, and consequently enantiopure drugs are
essential for treating disease. Nearly 50% of drugs are chiral wherein pharmacological …

Racemic benzylic amines undergo kinetic resolution via benzoylation with benzoic
anhydride in the presence of a dual catalyst system consisting of a readily available amide …

A new, dynamic diastereomeric crystallization method has been developed, in which the
mother liquors are continuously separated, racemized over a fixed-bed catalyst, and …

The selective removal of vanillin in bioconversion by forming 1: 2 co-crystals of phenazine–
vanillin may serve as a new technology. Initial solvent screening experiments of vanillin …

Biocatalytic synthesis is a powerful and frequently chosen method for the production of chiral
amines. Unfortunately, these biocatalytic reactions often result in complex mixtures, bearing …

Using a statistical Z-score methodology, enantiomeric excess (ee) data from our historical
high-throughput classical chiral resolution screens were analyzed. In total, 19 of the screens …

Both enantiomers of several phenylethylamines, structurally related to amphetamine, have
been prepared in good yields and excellent enantiomeric purity by enzymatic kinetic …

Lipase-catalyzed benzoylation of amines was shown to be feasible, in some cases with high
enantioselectivity, and the best results were obtained using immobilized lipase from …

The history and popularity of tartaric acid (1) and its application (Fig. I) started 150 years ago
with Pasteur's discovery of L and D enantiomers of 1 and of their optical activity. Toward the …