Cancer is a complex disease with a 5–10% hereditary base, but nutrition, lifestyle, and the
environment we are exposed to influence 90–95% of cancers. Due to rapid westernization …

Mitochondria are key organelles in eukaryotic cells principally responsible for multiple
cellular functions. In addition to a plethora of somatic mutations as well as polymorphic …

The role of the mitochondria in disease, general health and aging has drawn much attention
over the years. Several attempts have been made to describe how the numbers of …

Mitochondria are the critical organelles involved in various cellular functions. Mitochondrial
biogenesis is activated by multiple cellular mechanisms which require a synchronous …

Mitochondria control essential cellular activities including generation of ATP via oxidative
phosphorylation. Mitochondrial DNA (mtDNA) mutations in the regulatory D-loop region and …

Mitochondria are eukaryotic organelles responsible for energy production. Mitochondrial
DNA (mtDNA) lack introns and protective histones, have limited DNA repair capacity and …

Recent studies have demonstrated a potential link between circulating cell-free
mitochondrial DNA (mtDNA) content and cancers. However, there is no study evaluating the …

Accumulating epidemiological evidence indicates that the quantitative changes in human
mitochondrial DNA (mtDNA) copy number could affect the genetic susceptibility of …

Alterations in cellular aging, indexed by leukocyte telomere length (LTL) and mitochondrial
DNA copy number (mtDNAcn), might partly account for the increased health risks in persons …

Background: Increased mitochondrial DNA copy number (mtDNAcn) is a biologic response
to mtDNA damage and dysfunction, predictive of lung cancer risk. Polycyclic aromatic …