Spray drying formulation of amorphous solid dispersions

A Singh, G Van den Mooter - Advanced drug delivery reviews, 2016 - Elsevier
Spray drying is a well-established manufacturing technique which can be used to formulate
amorphous solid dispersions (ASDs) which is an effective strategy to deliver poorly water …

[HTML][HTML] Overview of extensively employed polymeric carriers in solid dispersion technology

AR Nair, YD Lakshman, VSK Anand, KSN Sree… - AAPS …, 2020 - Springer
Solid dispersion is the preferred technology to prepare efficacious forms of BCS class-II/IV
APIs. To prepare solid dispersions, there exist a wide variety of polymeric carriers with …

[HTML][HTML] Advances in the development of amorphous solid dispersions: The role of polymeric carriers

J Zhang, M Guo, M Luo, T Cai - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

The role of the carrier in the formulation of pharmaceutical solid dispersions. Part II: amorphous carriers

T Van Duong, G Van den Mooter - Expert opinion on drug delivery, 2016 - Taylor & Francis
Introduction: Amorphous solid dispersions are considered as one of the most powerful
strategies to formulate poorly soluble drugs. They are made up of an active pharmaceutical …

Applications of polymers as pharmaceutical excipients in solid oral dosage forms

N Debotton, A Dahan - Medicinal research reviews, 2017 - Wiley Online Library
Over the last few decades, polymers have been extensively used as pharmaceutical
excipients in drug delivery systems. Pharmaceutical polymers evolved from being simply …

Probing the interplay between amorphous solid dispersion stability and polymer functionality

DS Frank, AJ Matzger - Molecular pharmaceutics, 2018 - ACS Publications
Amorphous solid dispersions containing a polymeric component often impart improved
stability against crystallization for a small molecule relative to the pure amorphous form …

Polymorphism of indomethacin in semicrystalline dispersions: formation, transformation, and segregation

T Van Duong, D Lüdeker, PJ Van Bockstal… - Molecular …, 2018 - ACS Publications
The crystallization of metastable crystal polymorphs in polymer matrices has been
extensively reported in literature as a possible approach to enhance the solubility of poorly …

The role of the carrier in the formulation of pharmaceutical solid dispersions. Part I: crystalline and semi-crystalline carriers

T Van Duong, G Van den Mooter - Expert opinion on drug delivery, 2016 - Taylor & Francis
Introduction: As a consequence of the target and drug candidate identification process,
drugs with higher hydrophobicity and/or lipophilicity are being selected for further …

Effect of polymer hydrophobicity on the stability of amorphous solid dispersions and supersaturated solutions of a hydrophobic pharmaceutical

DS Frank, AJ Matzger - Molecular pharmaceutics, 2019 - ACS Publications
Amorphous solid dispersions of pharmaceuticals often show improved solubility over
crystalline forms. However, the crystallization of amorphous solid dispersions during …

[HTML][HTML] Indomethacin: Effect of diffusionless crystal growth on thermal stability during long-term storage

R Svoboda, N Koutná, D Košťálová, M Krbal… - Molecules, 2023 - mdpi.com
Differential scanning calorimetry and Raman spectroscopy were used to study the
nonisothermal and isothermal crystallization behavior of amorphous indomethacin powders …