Tobacco and nicotine use are associated with disease susceptibility and progression.
Health challenges associated with nicotine and smoking include developmental delays …

Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

The N-terminal portion of the octapeptide angiotensin II (DRVYIHPF; AngII), a vasopressor
peptide that favorably binds to, and activates, AngII type 1 receptor (AT1R), has an important …

Protein-coding differences between species often fail to explain phenotypic diversity,
suggesting the involvement of genomic elements that regulate gene expression such as …

Vocal production learning (“vocal learning”) is a convergently evolved trait in vertebrates. To
identify brain genomic elements associated with mammalian vocal learning, we integrated …

Human and non-human primates have strikingly similar genomes, but they strongly differ in
many brain-based processes (eg, behaviour and cognition). While the functions of protein …

Background Evolutionary conservation is an invaluable tool for inferring functional
significance in the genome, including regions that are crucial across many species and …

Although noncoding RNAs (ncRNAs) have been shown to regulate maladaptive
neuroadaptations that drive compulsive drug use, ncRNA-targeting therapeutics for …

Epigenetic gene regulation in the heterogeneous brain remains challenging to decipher with
current strategies. Bulk tissue analysis from pooled subjects reflects the average of cell-type …

NIDA's Avenir Program in the Genetics or Epigenetics of Substance Use Disorders (SUDs)
was launched to support early stage investigators who propose innovative, high risk, but …