Anthracyclines are the most fundamental and important treatment of several cancers
especially for lymphoma and breast cancer. However, their use is limited by a dose …

Novel therapeutic options have significantly improved survival and long-term outcomes in
many cancer entities. Unfortunately, this improvement in outcome is often accompanied by …

Abstract Purpose of Review In this review we describe the role of inflammation in
chemotherapy-induced cardiotoxicity with a particular focus on anthracycline-induced …

Damage to the mitochondria may lead to serious conditions that are difficult to treat.
Doxorubicin is one of the most widely used chemotherapeutic drugs for the treatment of …

The clinical usefulness of doxorubicin (DOX) is limited by its serious adverse effects, such as
cardiotoxicity. Pregnenolone demonstrated both anti-inflammatory and antioxidant activity in …

Speckle tracking-echocardiography (STE) is a novel non-invasive imaging tool capable of
quantifying myocardial deformation, and thus holds promise in detecting early subclinical …

Although the use of Doxorubicin (Dox) is extensive in the treatment of malignant tumor, the
toxic effects of Dox on the heart can cause myocardial injury. Therefore, it is necessary to …

Anthracyclines such as doxorubicin (Dox) are effective chemotherapeutic agents, however
their use is hampered by subsequent cardiotoxicity risk. Our understanding of cardiomyocyte …

In recent decades, the number of cancer survivors in the United States has steadily
increased with figures reaching about 18 million in 2022, and projections show continued …

The most important dose-limiting factor of the anthracycline idarubicin is the high risk of
cardiotoxicity, in which the secondary alcohol metabolite idarubicinol plays an important …