Obesity is associated with low-grade chronic inflammation. Indeed, adipose tissues (AT) in
obese individuals are the former site of progressive infiltration by pro-inflammatory immune …

Abstract T helper 17 (Th17) cells are important mediators of immune responses against
extracellular bacteria and fungi, and as such play critical regulatory roles in maintaining …

FOXP3+ regulatory T cells (Tregs) are central for peripheral tolerance, and their
deregulation is associated with autoimmunity. Dysfunctional autoimmune Tregs display pro …

Macrophages comprise a majority of the resident immune cells in adipose tissue (AT) and
regulate both tissue homeostasis in the lean state and metabolic dysregulation in obesity …

A robust adaptive immune response requires a phase of proliferative burst which is followed
by the polarization of T cells into relevant functional subsets. Both processes are associated …

Psoriasis lesions are rich in IL-17–producing T cells as well as neutrophils, which release
webs of DNA-protein complexes known as neutrophil extracellular traps (NETs). Because …

Aims CD4+ T cells are the major drivers of cardiac-specific autoimmunity in myocarditis,
specifically Th1, Treg, and most significant Th17 cells. But the molecular mechanisms of …

Sepsis has always been considered as a big challenge for pharmaceutical companies in
terms of discovering and designing new therapeutics. The pathogenesis of sepsis involves …

Dry eye disease (DED) is among the most common ocular disorders affecting tens of
millions of individuals worldwide; however, the condition remains incompletely understood …

Helper T (Th) cells play an important role in the pathogenesis of autoimmune diseases,
including rheumatoid arthritis (RA). It has been revealed that Th17 cells can shift to Th1 cells …