The TNF family of ligands and receptors: communication modules in the immune system and beyond
C Dostert, M Grusdat, E Letellier… - Physiological …, 2019 - journals.physiology.org
The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …
Tumor necrosis factor receptor-associated factor regulation of nuclear factor κB and mitogen-activated protein kinase pathways
Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally
related proteins that transduces signals from members of TNFR superfamily and various …
related proteins that transduces signals from members of TNFR superfamily and various …
Sublethal necroptosis signaling promotes inflammation and liver cancer
M Vucur, A Ghallab, AT Schneider, A Adili, M Cheng… - Immunity, 2023 - cell.com
It is currently not well known how necroptosis and necroptosis responses manifest in vivo.
Here, we uncovered a molecular switch facilitating reprogramming between two alternative …
Here, we uncovered a molecular switch facilitating reprogramming between two alternative …
Regulation of NF-κB by TNF family cytokines
The NF-κB family of inducible transcription factors is activated in response to a variety of
stimuli. Amongst the best-characterized inducers of NF-κB are members of the TNF family of …
stimuli. Amongst the best-characterized inducers of NF-κB are members of the TNF family of …
Regulation of tumour necrosis factor signalling: live or let die
Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has important roles in
mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) …
mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) …
Molecular basis of NF-κB signaling
J Napetschnig, H Wu - Annual review of biophysics, 2013 - annualreviews.org
NF-κB (nuclear factor kappa B) family transcription factors are master regulators of immune
and inflammatory processes in response to both injury and infection. In the latent state, NF …
and inflammatory processes in response to both injury and infection. In the latent state, NF …
Structural principles of tumor necrosis factor superfamily signaling
ÉS Vanamee, DL Faustman - Science signaling, 2018 - science.org
The tumor necrosis factor (TNF) ligand and receptor superfamilies play an important role in
cell proliferation, survival, and death. Stimulating or inhibiting TNF superfamily signaling …
cell proliferation, survival, and death. Stimulating or inhibiting TNF superfamily signaling …
Getting TRAIL back on track for cancer therapy
JV Lemke, S von Karstedt, J Zinngrebe… - Cell Death & …, 2014 - nature.com
Unlike other members of the TNF superfamily, the TNF-related apoptosis-inducing ligand
(TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis …
(TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis …
NF-κB, the first quarter-century: remarkable progress and outstanding questions
The ability to sense and adjust to the environment is crucial to life. For multicellular
organisms, the ability to respond to external changes is essential not only for survival but …
organisms, the ability to respond to external changes is essential not only for survival but …
CD137 (4-1BB)-based cancer immunotherapy on its 25th anniversary
I Melero, MF Sanmamed, J Glez-Vaz, C Luri-Rey… - Cancer Discovery, 2023 - AACR
Twenty-five years ago, we reported that agonist anti-CD137 monoclonal antibodies
eradicated transplanted mouse tumors because of enhanced CD8+ T-cell antitumor …
eradicated transplanted mouse tumors because of enhanced CD8+ T-cell antitumor …