Its increasing incidence has led stroke to be the second leading cause of death worldwide.
Despite significant advances in recanalization strategies, patients are still at risk for …

The blood-brain barrier (BBB) has been a great hurdle for brain drug delivery. The BBB in
healthy brain is a diffusion barrier essential for protecting normal brain function by impeding …

In patients with glioblastoma, resistance to the chemotherapeutic temozolomide (TMZ) limits
any survival benefits conferred by the drug. Here we show that the convection-enhanced …

A variety of neuroprotectants have shown promise in treating ischemic stroke, yet their
delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier …

Neuropsychiatric diseases are one of the main causes of disability, affecting millions of
people. Various drugs are used for its treatment, although no effective therapy has been …

With the rise in the aging global population, stroke comorbidities have become a serious
health threat and a tremendous economic burden on human society. Current therapeutic …

Introduction: Current therapies of neurodegenerative or neurometabolic diseases are, to a
large extent, hampered by the inability of drugs to cross the blood-brain barrier (BBB). This …

The design and development of delivery controlled systems of molecules of interest has
attracted great interest over the last years. pH variation, light irradiation, temperature …

Endosomal escape is a key step for intracellular drug delivery of nucleic acids, but reliable
and sensitive methods for its quantitation remain an unmet need. In order to rationally …

We develop multidrug-loaded cubosome and spongosome lipid nanoparticles for targeting
of endoplasmic reticulum stress as a potential emerging therapeutic strategy against …