Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that function to
maintain and remodel tissue architecture. Their substrates represent an astounding variety …

Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced
limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy …

Keratocytes of the corneal stroma secrete a specialized extracellular matrix essential for
vision. These quiescent cells exhibit limited capacity for self‐renewal and after cell division …

PAX6 function was first identified through aniridia-associated null mutations. Since then, this
transcription factor, with a paired domain and a homeodomain, has become a paradigm …

Development requires the careful orchestration of several biological events in order to
create any structure and, eventually, to build an entire organism. On the other hand, the fate …

purpose. To investigate corneal abnormalities in heterozygous Pax6+/Sey-Neu (Pax6+/−,
small eye) mice and compare them with aniridia-related keratopathy in PAX6+/− patients …

purpose. To investigate the etiology of corneal dysfunction in the Pax6+/− mouse model of
aniridia-related keratopathy. methods. Mosaic patterns of X-gal staining were compared in …

Pax6 is a sequence-specific DNA binding transcription factor that positively and negatively
regulates transcription and is expressed in multiple cell types in the developing and adult …

The Pax6 transcription factor functions early during embryogenesis to control key steps in
brain, pancreas, olfactory and ocular system development. A requirement for Pax6 in proper …

Loss of retinal ganglion cells is the final end point in blinding diseases of the optic nerve
such as glaucoma. To enable the use of mouse genetics to investigate mechanisms …