In addition to their roles in IGF transport, the six IGF-binding proteins (IGFBPs) regulate cell
activity in various ways. By sequestering IGFs away from the type I IGF receptor, they may …

This review focuses on the systemic complications of acromegaly. Mortality in this disease is
increased mostly because of cardiovascular and respiratory diseases, although currently …

The insulin-like growth factors (IGFs) are mitogens that play a pivotal role in regulating cell
proliferation, differentiation, and apoptosis. The effects of IGFs are mediated through the IGF …

Insulin-like growth factor–I (IGF-I) is a mitogen for prostate epithelial cells. To investigate
associations between plasma IGF levels and prostate cancer risk, a nested case-control …

Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily* | Endocrine Reviews | Oxford
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Overweight and obese men with prostate cancer are at an increased risk of disease
recurrence, exacerbated treatment-related adverse effects, development of obesity-related …

Insulin-Like Growth Factor-Binding Proteins in Serum and Other Biological Fluids: Regulation
and Functions* | Endocrine Reviews | Oxford Academic Skip to Main Content Advertisement …

Insulin and insulin-like growth factor (IGF) axes are major determinants of proliferation and
apoptosis and thus may influence carcinogenesis. In various animal models, modulation of …

Autophagy and apoptosis are catabolic pathways essential for organismal homeostasis.
Autophagy is normally a cell‐survival pathway involving the degradation and recycling of …

As prostate cancer and aberrant changes in reactive oxygen species (ROS) become more
common with aging, ROS signaling may play an important role in the development and …