Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
Exosomal circular RNAs: a chief culprit in cancer chemotherapy resistance
X Guo, C Gao, DH Yang, S Li - Drug Resistance Updates, 2023 - Elsevier
Chemotherapy is one of the primary treatments for malignant tumors. However, the acquired
drug resistance hinders clinical efficacy and leads to treatment failure in most patients …
drug resistance hinders clinical efficacy and leads to treatment failure in most patients …
Clinical delivery of circular RNA: lessons learned from RNA drug development
Circular RNAs (circRNA) represent a distinct class of covalently closed-loop RNA molecules,
which play diverse roles in regulating biological processes and disease states. The …
which play diverse roles in regulating biological processes and disease states. The …
mRNA-based vaccines and therapeutics for COVID-19 and future pandemics
An unheard mobilization of resources to find SARS-CoV-2 vaccines and therapies has been
sparked by the COVID-19 pandemic. Two years ago, COVID-19's launch propelled mRNA …
sparked by the COVID-19 pandemic. Two years ago, COVID-19's launch propelled mRNA …
Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics
The accelerated progress and approval of two mRNA-based vaccines to address the SARS-
CoV-2 virus were unprecedented. This record-setting feat was made possible through the …
CoV-2 virus were unprecedented. This record-setting feat was made possible through the …
Functionalization of polymers for intracellular protein delivery
Y Zhang, J Shi, B Ma, YN Zhou, H Yong, J Li… - Progress in Polymer …, 2023 - Elsevier
With the growing demand for clinically reliable therapeutics, traditional small molecule drugs
are increasingly limited by their short circulation duration, low bioavailability, and poor …
are increasingly limited by their short circulation duration, low bioavailability, and poor …
Nanomaterials for mRNA‐based therapeutics: Challenges and opportunities
D Li, Q Liu, M Yang, H Xu, M Zhu… - Bioengineering & …, 2023 - Wiley Online Library
Messenger RNA (mRNA) holds great potential in developing immunotherapy, protein
replacement, and genome editing. In general, mRNA does not have the risk of being …
replacement, and genome editing. In general, mRNA does not have the risk of being …
Role of circular RNAs in disease progression and diagnosis of cancers: An overview of recent advanced insights
Tumor microenvironment (TME) is a crucial regulator of tumor progression and cells in the
TME release a number of molecules that are responsible for anaplasticity, invasion …
TME release a number of molecules that are responsible for anaplasticity, invasion …
Functions of circular RNA in human diseases and illnesses
A Gu, DK Jaijyan, S Yang, M Zeng, S Pei, H Zhu - Non-coding RNA, 2023 - mdpi.com
Circular RNAs (circRNAs) represent single-stranded RNA species that contain covalently
closed 3′ and 5′ ends that provide them more stability than linear RNA, which has free …
closed 3′ and 5′ ends that provide them more stability than linear RNA, which has free …
[HTML][HTML] CircRNAs: Pivotal modulators of TGF-β signalling in cancer pathogenesis
The intricate molecular landscape of cancer pathogenesis continues to captivate
researchers worldwide, with Circular RNAs (circRNAs) emerging as pivotal players in the …
researchers worldwide, with Circular RNAs (circRNAs) emerging as pivotal players in the …