Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy

Y Zong, Y Lin, T Wei, Q Cheng - Advanced Materials, 2023 - Wiley Online Library
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …

Exosomal circular RNAs: a chief culprit in cancer chemotherapy resistance

X Guo, C Gao, DH Yang, S Li - Drug Resistance Updates, 2023 - Elsevier
Chemotherapy is one of the primary treatments for malignant tumors. However, the acquired
drug resistance hinders clinical efficacy and leads to treatment failure in most patients …

Clinical delivery of circular RNA: lessons learned from RNA drug development

TL Young, KC Wang, AJ Varley, B Li - Advanced drug delivery reviews, 2023 - Elsevier
Circular RNAs (circRNA) represent a distinct class of covalently closed-loop RNA molecules,
which play diverse roles in regulating biological processes and disease states. The …

mRNA-based vaccines and therapeutics for COVID-19 and future pandemics

VP Chavda, S Soni, LK Vora, S Soni, A Khadela… - Vaccines, 2022 - mdpi.com
An unheard mobilization of resources to find SARS-CoV-2 vaccines and therapies has been
sparked by the COVID-19 pandemic. Two years ago, COVID-19's launch propelled mRNA …

Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics

DD Kang, H Li, Y Dong - Advanced Drug Delivery Reviews, 2023 - Elsevier
The accelerated progress and approval of two mRNA-based vaccines to address the SARS-
CoV-2 virus were unprecedented. This record-setting feat was made possible through the …

Functionalization of polymers for intracellular protein delivery

Y Zhang, J Shi, B Ma, YN Zhou, H Yong, J Li… - Progress in Polymer …, 2023 - Elsevier
With the growing demand for clinically reliable therapeutics, traditional small molecule drugs
are increasingly limited by their short circulation duration, low bioavailability, and poor …

Nanomaterials for mRNA‐based therapeutics: Challenges and opportunities

D Li, Q Liu, M Yang, H Xu, M Zhu… - Bioengineering & …, 2023 - Wiley Online Library
Messenger RNA (mRNA) holds great potential in developing immunotherapy, protein
replacement, and genome editing. In general, mRNA does not have the risk of being …

Role of circular RNAs in disease progression and diagnosis of cancers: An overview of recent advanced insights

SU Khan, MU Khan, MI Khan, AA Fadahunsi… - International journal of …, 2022 - Elsevier
Tumor microenvironment (TME) is a crucial regulator of tumor progression and cells in the
TME release a number of molecules that are responsible for anaplasticity, invasion …

Functions of circular RNA in human diseases and illnesses

A Gu, DK Jaijyan, S Yang, M Zeng, S Pei, H Zhu - Non-coding RNA, 2023 - mdpi.com
Circular RNAs (circRNAs) represent single-stranded RNA species that contain covalently
closed 3′ and 5′ ends that provide them more stability than linear RNA, which has free …

[HTML][HTML] CircRNAs: Pivotal modulators of TGF-β signalling in cancer pathogenesis

AA Bhat, G Gupta, R Dahiya, R Thapa, A Gahtori… - Non-coding RNA …, 2024 - Elsevier
The intricate molecular landscape of cancer pathogenesis continues to captivate
researchers worldwide, with Circular RNAs (circRNAs) emerging as pivotal players in the …