Clinical outcome measures in multiple sclerosis: a review

H Inojosa, D Schriefer, T Ziemssen - Autoimmunity reviews, 2020 - Elsevier
A proper clinical evaluation of patients with Multiple Sclerosis (MS) is of great importance to
detect MS progression. It provides important data for physicians on their daily practice as …

A literature review of cost-of-illness studies on the economic burden of multiple sclerosis.

M Paz-Zulueta, P Parás-Bravo… - Multiple sclerosis and …, 2020 - Elsevier
Background Multiple sclerosis has both high healthcare and social impacts. Objective The
purpose of this article is to analyse the available literature describing the economic burden …

[HTML][HTML] Systematic review and network meta-analysis comparing ocrelizumab with other treatments for relapsing multiple sclerosis

R McCool, K Wilson, M Arber, K Fleetwood… - Multiple sclerosis and …, 2019 - Elsevier
Background Ocrelizumab was approved for the treatment of relapsing multiple sclerosis
(RMS) and primary progressive multiple sclerosis (PPMS) by the US Food and Drug …

Synthetic MRI in the detection of multiple sclerosis plaques

A Hagiwara, M Hori, K Yokoyama… - American journal …, 2017 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Synthetic MR imaging enables the creation of various
contrast-weighted images including double inversion recovery and phase-sensitive …

[HTML][HTML] Optimizing therapy early in multiple sclerosis: an evidence-based view

T Ziemssen, N De Stefano, MP Sormani… - Multiple sclerosis and …, 2015 - Elsevier
Therapies that target the underlying pathology of multiple sclerosis (MS), including focal and
diffuse damage, may improve long-term disease control. Focal damage (inflammatory …

Fingolimod for relapsing‐remitting multiple sclerosis

L La Mantia, I Tramacere, B Firwana… - Cochrane Database …, 2016 - cochranelibrary.com
Background Fingolimod was approved in 2010 for the treatment of patients with the
relapsing‐remitting (RR) form of multiple sclerosis (MS). It was designed to reduce the …

Comparative efficacy and safety of disease-modifying therapies in patients with relapsing multiple sclerosis: a systematic review and network meta-analysis

C Chen, E Zhang, C Zhu, R Wei, L Ma, X Dong… - Journal of the American …, 2023 - Elsevier
Background Currently, 19 disease-modifying therapies (DMTs) have been approved for the
treatment of patients with relapsing forms of multiple sclerosis (RMS). Objective The …

Disability outcome measures in phase III clinical trials in multiple sclerosis

BMJ Uitdehaag - CNS drugs, 2018 - Springer
Accumulating neurological disability has a substantial impact on the lives of patients with
multiple sclerosis (MS). As well as the established Expanded Disability Status Scale (EDSS) …

Gait abnormalities in minimally disabled people with Multiple Sclerosis: A 3D-motion analysis study

M Liparoti, M Della Corte, R Rucco, P Sorrentino… - Multiple sclerosis and …, 2019 - Elsevier
Abstract Background People with Relapsing-Remitting Multiple Sclerosis (pwRR-MS), may
be affected by subclinical gait impairment. The Expanded Disability Status Scale, the most …

Laboratory biomarkers of multiple sclerosis (MS)

B Arneth, J Kraus - Clinical biochemistry, 2022 - Elsevier
Multiple Sclerosis (MS) is a neurological disease that affects the central nervous system
(CNS). The diagnosis of the disease is quite challenging due to its variation among patients …